Sweet D E, Madewell J E, Ragsdale B D
Radiol Clin North Am. 1981 Dec;19(4):785-814.
The mineralized matrix patterns demonstrated in clinical radiographs of primary bone neoplasms and related disorders help to predict matrices, and have diagnostic significance. These radiographic patterns may yield important clues as to the true nature of a lesion, especially when only limited biopsy material is available from extraosseous or nonrepresentative areas. Therefore, in the evaluation of bone tumors and tumor-like conditions, it is of extreme importance to correlate the histologic findings with the radiographic examination and to know precisely the location at which the biopsy material was obtained. Patterns of mineralization may be the only remnants of a pre-existing lesion that has undergone sarcomatous transformation, such as in bone infarcts, enchondromas, or osteochondromas. The pre-eminent item of importance for patient care is the diagnosis of a malignant process. However, failure to appreciate antecedent benign conditions will not contribute toward a better understanding of tumor biology or a determination of those benign lesions that warrant removal or close clinical follow-up. Integration of matrix data with knowledge of the anatomic location of a lesion, the character of its margins, and the periosteal reaction patterns it produces permits prognostication and often, specific diagnosis.
原发性骨肿瘤及相关疾病的临床X线片中显示的矿化基质模式有助于预测基质，具有诊断意义。这些X线表现可能为病变的真实性质提供重要线索，尤其是当仅从骨外或非代表性区域获得有限的活检材料时。因此，在评估骨肿瘤和肿瘤样病变时，将组织学结果与X线检查相关联，并确切知道活检材料的获取位置极为重要。矿化模式可能是已发生肉瘤样转化的先前病变的唯一残余物，如骨梗死、内生软骨瘤或骨软骨瘤。对患者护理而言，最重要的是诊断恶性病变。然而，未能认识到先前的良性情况无助于更好地理解肿瘤生物学，也无助于确定那些需要切除或密切临床随访的良性病变。将基质数据与病变的解剖位置、边缘特征及其产生的骨膜反应模式相结合，有助于进行预后判断，且常常能做出明确诊断。
