Nelson D W, Nichols R D, Fine G
Laryngoscope. 1978 Dec;88(12):1935-41. doi: 10.1288/00005537-197812000-00006.
Acinous cell tumors are uncommon neoplasms which arise either from the secretory cells of the salivary gland acini or from pluripotential duct cells and occur almost exclusively in the parotid gland. Nine previous instances of the bilateral occurrence of this tumor in the parotid gland have been reported. We present a tenth case and illustrate several aspects of the clinical behavior of this unique tumor. The histological pattern of this type of tumor was considered universally to be benign until 1953 when attention was called to a malignant variant. It is difficult to find reference to a benign form after that time. It is, in fact, impossible to forecast the clinical behavior of an individual specimen based upon its histopathology. In order to recognize this unpredictability, the World Health Organization Classification of Epithelial Tumors of Salivary Gland Origin proposed a category, "Acinic Cell Tumors," separate from clearly benign or malignant neoplasms. Later, attention was called to the grammatical designation, "acinous cell tumor." Because acinous cell tumors are uncommon, numerically significant series are gathered from several institutions or over several decades during which treatment methods vary widely. This makes it difficult to accept the validity of conclusions based upon the reported data. There is, however, a clearly documented tendency of the tumor to recur after long symptomless intervals so that extended follow-up is necessary before "cure" is established. Treatment of acinous cell tumors is surgical. The value of radiation therapy in the management of recurrent tumors is not firmly established.
腺泡细胞肿瘤是一种罕见的肿瘤，它起源于唾液腺腺泡的分泌细胞或多潜能导管细胞，几乎仅发生于腮腺。此前已有9例双侧腮腺发生该肿瘤的报道。我们现报告第10例病例，并阐述这种独特肿瘤临床行为的几个方面。直到1953年人们注意到一种恶性变体之前，这种类型肿瘤的组织学模式一直被普遍认为是良性的。此后很难找到关于良性形式的参考文献。事实上，根据其组织病理学来预测单个标本的临床行为是不可能的。为了认识到这种不可预测性，世界卫生组织唾液腺源性上皮肿瘤分类法提出了一个与明确的良性或恶性肿瘤不同的类别——“腺泡细胞肿瘤”。后来，人们注意到其语法名称“腺泡细胞肿瘤”。由于腺泡细胞肿瘤不常见，大量有意义的病例系列是从几个机构收集的，或者跨越了几十年，在此期间治疗方法差异很大。这使得难以接受基于所报告数据得出的结论的有效性。然而，有明确记录表明该肿瘤有在长时间无症状间隔后复发的倾向，因此在确定“治愈”之前需要进行长期随访。腺泡细胞肿瘤的治疗方法是手术。放射治疗在复发性肿瘤治疗中的价值尚未得到确切证实。
