Andrade Z A, Brito P A
Am J Trop Med Hyg. 1981 Nov;30(6):1223-7. doi: 10.4269/ajtmh.1981.30.1223.
Mice infected with 30 cercariae of Schistosoma mansoni showed extensive destruction, obstruction, and distortion of the intrahepatic portal vein system 10 weeks after exposure. One month after curative treatment for schistosomiasis, these lesions had considerably regressed. The vascular pattern was almost normal by 2 months and completely normal by 6 months following treatment. The techniques used to study vascular changes included plastic casting, injection of colored gelatin, and conventional histopathologic methods. Main transformations observed after treatment were shrinkage of periovular granulomas and formation of new vascular channels around them, which restored the continuity of the portal vein system. Shrunken granulomas remained avascular.
感染30条曼氏血吸虫尾蚴的小鼠在接触后10周，肝内门静脉系统出现广泛破坏、阻塞和扭曲。血吸虫病根治治疗1个月后，这些病变明显消退。治疗后2个月时血管形态几乎恢复正常，6个月时完全正常。用于研究血管变化的技术包括塑料铸型、彩色明胶注射和传统组织病理学方法。治疗后观察到的主要变化是卵周肉芽肿缩小以及其周围形成新的血管通道，从而恢复了门静脉系统的连续性。缩小的肉芽肿仍无血管。
