Pichugina T V, Novitskiĭ V V, Gol'dberg E D
Antibiotiki. 1979 Sep;24(9):664-8.
The proliferative activity and level of aberrant mitoses in the cells of the bone marrow were studied experimentally on 223 noninbred mice treated with carminomycin administered intraperitoneally in single (LD50) and repeated doses. When the antibiotic was used in a single dose the values of the mitotic activity of the bone marrow elements did not correspond to the severity of depression and thir quantitative composition, which was explained by an impairement of the mitosis quality and possible interkinetic destruction of a significant part of both erythroid and immature myeloid cells capable of division at early stages after the exposure. At the same time the level of the bone marrow devastation under conditions of the treatment with repeated doses was mainly determined by inhibition of the erythronormoblast proliferative activity.
在223只非近交系小鼠上进行了实验研究，这些小鼠经腹腔注射单剂量（半数致死量，LD50）和重复剂量的洋红霉素，观察骨髓细胞的增殖活性和异常有丝分裂水平。当使用单剂量抗生素时，骨髓细胞的有丝分裂活性值与抑制严重程度及其定量组成不相符，这是由于有丝分裂质量受损以及暴露后早期能够分裂的相当一部分红系和未成熟髓系细胞可能发生间期破坏所致。同时，重复剂量治疗条件下的骨髓破坏程度主要由红系成红细胞增殖活性的抑制所决定。
