肥胖（ob/ob）小鼠肝细胞中血管加压素对[1-14C]油酸代谢作用的损害。
Impairment of effects of vasopressin on [1-14C]oleate metabolism in hepatocytes from obese (ob/ob) mice.
作者信息
Edwards M W, Cawthorne M A, Williamson D H
出版信息
Biochem J. 1981 Jul 15;198(1):239-42. doi: 10.1042/bj1980239.
Abstract
In hepatocytes from lean mice vasopressin decreased ketogenesis and increased 14CO2 production from [1-14C]oleate and glucose release; these effects were Ca2+-dependent. None of these effects of vasopressin were obtained with hepatocytes from obese (ob/ob) mice. Similarly, adrenaline did not increase 14CO2 production in these hepatocytes, but it stimulated glucose release. Possible reasons for the impairment of vasopressin action are discussed.
摘要
在瘦小鼠的肝细胞中，血管加压素降低了生酮作用，并增加了[1-14C]油酸生成的14CO2产量以及葡萄糖释放；这些效应依赖于Ca2+。肥胖（ob/ob）小鼠的肝细胞未出现血管加压素的这些效应。同样，肾上腺素也未增加这些肝细胞中14CO2的产量，但它刺激了葡萄糖释放。文中讨论了血管加压素作用受损的可能原因。
相似文献
1
Impairment of effects of vasopressin on [1-14C]oleate metabolism in hepatocytes from obese (ob/ob) mice.肥胖（ob/ob）小鼠肝细胞中血管加压素对[1-14C]油酸代谢作用的损害。
Biochem J. 1981 Jul 15;198(1):239-42. doi: 10.1042/bj1980239.
2
Stimulation of [1-14C]oleate oxidation to 14CO2 in isolated rat hepatocytes by the catecholamines, vasopressin and angiotensin. A possible mechanism of action.儿茶酚胺、血管加压素和血管紧张素对离体大鼠肝细胞中[1-14C]油酸氧化生成14CO2的刺激作用。一种可能的作用机制。
Biochem J. 1983 Apr 15;212(1):85-91. doi: 10.1042/bj2120085.
3
Effects of phorbol esters, A23187 and vasopressin on oleate metabolism in isolated rat hepatocytes.佛波酯、A23187和血管加压素对分离的大鼠肝细胞中油酸代谢的影响。
Lipids. 1987 Jul;22(7):474-9. doi: 10.1007/BF02540362.
4
Effects of hyperthyroidism on stimulation of [1-14C]oleate oxidation to 14CO2 in isolated hepatocytes from fed rats by the catecholamines, vasopressin, and angiotensin II.甲状腺功能亢进对进食大鼠分离肝细胞中儿茶酚胺、血管加压素和血管紧张素II刺激[1-14C]油酸氧化为14CO2的影响。
Biosci Rep. 1983 Aug;3(8):757-65. doi: 10.1007/BF01120987.
5
Alpha 1-adrenergic regulation of ketogenesis in isolated rat hepatocytes.α1-肾上腺素能对分离的大鼠肝细胞中酮体生成的调节
Biochim Biophys Acta. 1991 Mar 19;1092(1):94-100. doi: 10.1016/0167-4889(91)90182-w.
6
7
Effects of vasopressin and corticosterone on fatty acid metabolism and on the activities of glycerol phosphate acyltransferase and phosphatidate phosphohydrolase in rat hepatocytes.血管加压素和皮质酮对大鼠肝细胞脂肪酸代谢以及磷酸甘油酰基转移酶和磷脂酸磷酸水解酶活性的影响。
Biochem J. 1984 Jan 15;217(2):461-9. doi: 10.1042/bj2170461.
8
Effects of exogenous phospholipase enzymes, arachidonic acid and 1-oleoyl-2-acetyl-sn-glycerol on ketogenesis in isolated rat hepatocytes.外源性磷脂酶、花生四烯酸和1-油酰基-2-乙酰基-sn-甘油对分离的大鼠肝细胞生酮作用的影响。
Biochim Biophys Acta. 1989 Jun 15;1012(1):5-9. doi: 10.1016/0167-4889(89)90003-7.
9
Effects of vasopressin, angiotensin II and phenylephrine on hepatic ketogenesis and fatty acid synthesis.血管加压素、血管紧张素II和去氧肾上腺素对肝脏生酮作用及脂肪酸合成的影响。
Jpn J Pharmacol. 1986 Aug;41(4):525-32. doi: 10.1254/jjp.41.525.
10
Oleate metabolism in isolated hepatocytes from lean and obese Zucker rats. Influence of a high fat diet and in vitro response to glucagon.瘦型和肥胖型 Zucker 大鼠分离肝细胞中的油酸代谢。高脂饮食的影响及对胰高血糖素的体外反应。
Metabolism. 1983 Jul;32(7):661-8. doi: 10.1016/0026-0495(83)90121-x.
引用本文的文献
1
Mitochondrial Ca2+ transport in lean and genetically obese (ob/ob) mice.瘦小鼠和遗传性肥胖（ob/ob）小鼠中的线粒体钙转运
Biochem J. 1983 Jul 15;214(1):163-70. doi: 10.1042/bj2140163.
2
Effects of vasopressin and corticosterone on fatty acid metabolism and on the activities of glycerol phosphate acyltransferase and phosphatidate phosphohydrolase in rat hepatocytes.血管加压素和皮质酮对大鼠肝细胞脂肪酸代谢以及磷酸甘油酰基转移酶和磷脂酸磷酸水解酶活性的影响。
Biochem J. 1984 Jan 15;217(2):461-9. doi: 10.1042/bj2170461.
3
Lack of vasopressin receptors in liver, but not in kidney, of ob/ob mice.ob/ob小鼠肝脏中缺乏血管加压素受体，但肾脏中不存在这种情况。
Biochem J. 1983 Nov 15;216(2):475-80. doi: 10.1042/bj2160475.
本文引用的文献
1
Enzymic determination of D(-)-beta-hydroxybutyric acid and acetoacetic acid in blood.血液中D(-)-β-羟基丁酸和乙酰乙酸的酶法测定
Biochem J. 1962 Jan;82(1):90-6. doi: 10.1042/bj0820090.
2
Effect of food restriction on body composition of hereditary obese mice.食物限制对遗传性肥胖小鼠身体组成的影响。
Am J Physiol. 1955 Nov;183(2):284-90. doi: 10.1152/ajplegacy.1955.183.2.284.
3
Stimulation of [1-14C]oleate oxidation to 14CO2 in isolated rat hepatocytes by vasopressin: effects of Ca2+.血管加压素对离体大鼠肝细胞中[1-14C]油酸氧化为14CO2的刺激作用：钙离子的影响。
FEBS Lett. 1980 Jul 11;116(1):37-40. doi: 10.1016/0014-5793(80)80523-0.
4
Interactions between vasopressin and glucagon on ketogenesis and oleate metabolism in isolated hepatocytes from fed rats.血管升压素与胰高血糖素对喂食大鼠分离肝细胞中酮体生成和油酸代谢的相互作用。
Biochem J. 1980 Feb 15;186(2):621-4. doi: 10.1042/bj1860621.
5
Alpha-adrenergic stimulation of [1-14C]oleate oxidation to 14CO2 in isolated rat hepatocytes.α-肾上腺素能刺激分离的大鼠肝细胞中[1-¹⁴C]油酸氧化生成¹⁴CO₂ 。
FEBS Lett. 1980 Oct 20;120(1):80-4. doi: 10.1016/0014-5793(80)81051-9.
6
High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.大鼠肝脏实质细胞分离的高效制备：生化与精细结构研究
J Cell Biol. 1969 Dec;43(3):506-20. doi: 10.1083/jcb.43.3.506.
7
Synthesis of fatty acids in the perused mouse liver.在被研究的小鼠肝脏中脂肪酸的合成。
Biochem J. 1974 Sep;142(3):611-8. doi: 10.1042/bj1420611.
8
Inhibition of fatty acid synthesis and stimulation of glycogen breakdown by vasopressin in the perfused mouse liver.血管加压素对灌注小鼠肝脏中脂肪酸合成的抑制作用及对糖原分解的刺激作用。
Biochem J. 1975 Nov;152(2):389-92. doi: 10.1042/bj1520389.
9
Metabolic actions of vasopressin, glucagon and adrenalin in the intact rat.血管加压素、胰高血糖素和肾上腺素在正常大鼠体内的代谢作用。
Biochim Biophys Acta. 1975 Nov 10;411(1):155-64. doi: 10.1016/0304-4165(75)90294-9.
10
Resistance to hepatic action of vasopressin in genetically obese (ob/ob) mice.遗传性肥胖（ob/ob）小鼠对血管加压素肝脏作用的抵抗性。
Biochem J. 1976 Oct 15;160(1):23-8. doi: 10.1042/bj1600023.
Zotero 插件