血管加压素对灌注小鼠肝脏中脂肪酸合成的抑制作用及对糖原分解的刺激作用。
Inhibition of fatty acid synthesis and stimulation of glycogen breakdown by vasopressin in the perfused mouse liver.
作者信息
Ma G Y, Hems D A
出版信息
Biochem J. 1975 Nov;152(2):389-92. doi: 10.1042/bj1520389.
Abstract
- Vasopressin (anti-diuretic hormone, [8-arginine]vasopressin) inhibited the synthesis de novo of fatty acids (measured with (3)H(2)O and U-(14)C-labelled lactate or U-(14)C-labelled glucose) and stimulated glycogen breakdown in the perfused liver of fed mice. 2. The concentration dependence of these effects (range 200-1000muunits/ml, i.e. 0.5-2.5ng/ml) resembled that for the action on glycogen breakdown which was previously reported for rat liver. 3. The appearance of newly synthesized fatty acids in both phospholipids and triglycerides was inhibited by vasopressin, whereas synthesis of cholesterol was less affected. 4. Inhibition of hepatic lipogenesis by vasopressin is the most potent short-term hormonal action on this process yet reported. Aspects of the effect are discussed, including the lack of a role for cyclic AMP, and a possible link with vasopressin action on glycogen metabolism.
摘要
- 血管加压素（抗利尿激素，[8-精氨酸]血管加压素）抑制了脂肪酸的从头合成（用³H₂O和U-¹⁴C标记的乳酸或U-¹⁴C标记的葡萄糖进行测定），并刺激了喂食小鼠灌注肝脏中的糖原分解。2. 这些作用的浓度依赖性（范围为200 - 1000微单位/毫升，即0.5 - 2.5纳克/毫升）类似于先前报道的对大鼠肝脏糖原分解的作用。3. 血管加压素抑制了磷脂和甘油三酯中新合成脂肪酸的出现，而胆固醇的合成受影响较小。4. 血管加压素对肝脏脂肪生成的抑制是迄今为止报道的对该过程最有效的短期激素作用。讨论了该作用的各个方面，包括环磷酸腺苷的作用缺失以及与血管加压素对糖原代谢作用的可能联系。
相似文献
1
Inhibition of fatty acid synthesis and stimulation of glycogen breakdown by vasopressin in the perfused mouse liver.血管加压素对灌注小鼠肝脏中脂肪酸合成的抑制作用及对糖原分解的刺激作用。
Biochem J. 1975 Nov;152(2):389-92. doi: 10.1042/bj1520389.
2
Synthesis of fatty acids in the perused mouse liver.在被研究的小鼠肝脏中脂肪酸的合成。
Biochem J. 1974 Sep;142(3):611-8. doi: 10.1042/bj1420611.
3
Stimulation by vasopressin of glycogen breakdown and gluconeogenesis in the perfused rat liver.抗利尿激素对灌注大鼠肝脏中糖原分解和糖异生的刺激作用。
Biochem J. 1973 Nov;136(3):705-9. doi: 10.1042/bj1360705.
4
Resistance to hepatic action of vasopressin in genetically obese (ob/ob) mice.遗传性肥胖（ob/ob）小鼠对血管加压素肝脏作用的抵抗性。
Biochem J. 1976 Oct 15;160(1):23-8. doi: 10.1042/bj1600023.
5
Effects of glucagon and insulin on fatty acid synthesis and glycogen degradation in the perfused liver of normal and genetically obese (ob/ob) mice.胰高血糖素和胰岛素对正常及遗传性肥胖（ob/ob）小鼠灌注肝脏中脂肪酸合成及糖原降解的影响。
Biochem J. 1978 Sep 15;174(3):761-8. doi: 10.1042/bj1740761.
6
The immediate effects of insulin and fructose on the metabolism of the perfused liver. Changes in lipoprotein secretion, fatty acid oxidation and esterification, lipogenesis and carbohydrate metabolism.胰岛素和果糖对灌注肝脏代谢的即时影响。脂蛋白分泌、脂肪酸氧化与酯化、脂肪生成及碳水化合物代谢的变化。
Biochem J. 1972 Jan;126(2):295-311. doi: 10.1042/bj1260295.
7
Rapid stimulation by vasopressin, oxytocin and angiotensin II of glycogen degradation in hepatocyte suspensions.血管加压素、催产素和血管紧张素II对肝细胞悬液中糖原降解的快速刺激作用。
Biochem J. 1978 May 15;172(2):311-7. doi: 10.1042/bj1720311.
8
Inhibition of lipogenesis by vasopressin and angiotensin II in glycogen-depleted hepatocytes.血管加压素和血管紧张素II对糖原耗竭肝细胞脂肪生成的抑制作用。
Biosci Rep. 1983 Nov;3(11):1063-70. doi: 10.1007/BF01121033.
9
Glycogen phosphorylase, glucose output and vasoconstriction in the perfused rat liver. Concentration-dependence of actions of adrenaline, vasopressin and angiotensin II.灌注大鼠肝脏中的糖原磷酸化酶、葡萄糖输出与血管收缩。肾上腺素、血管加压素及血管紧张素II作用的浓度依赖性
Biochem J. 1976 Nov 15;160(2):367-74. doi: 10.1042/bj1600367.
10
Effects of vasopressin, angiotensin II and phenylephrine on hepatic ketogenesis and fatty acid synthesis.血管加压素、血管紧张素II和去氧肾上腺素对肝脏生酮作用及脂肪酸合成的影响。
Jpn J Pharmacol. 1986 Aug;41(4):525-32. doi: 10.1254/jjp.41.525.
引用本文的文献
1
Higher ambient temperature is associated with worsening of HbA1c levels in a Saudi population.在沙特人群中，环境温度升高与糖化血红蛋白（HbA1c）水平恶化有关。
Int J Clin Exp Pathol. 2021 Aug 15;14(8):881-891. eCollection 2021.
2
Hydration, Arginine Vasopressin, and Glucoregulatory Health in Humans: A Critical Perspective.水合作用、精氨酸加压素和人类的糖调节健康：批判性视角。
Nutrients. 2019 May 28;11(6):1201. doi: 10.3390/nu11061201.
3
Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats.加压素和水合作用在肥胖大鼠葡萄糖不耐受和肝脂肪变性的发展中起主要作用。
Diabetologia. 2015 May;58(5):1081-90. doi: 10.1007/s00125-015-3496-9. Epub 2015 Jan 27.
4
Interactions between vasopressin and glucagon on ketogenesis and oleate metabolism in isolated hepatocytes from fed rats.血管升压素与胰高血糖素对喂食大鼠分离肝细胞中酮体生成和油酸代谢的相互作用。
Biochem J. 1980 Feb 15;186(2):621-4. doi: 10.1042/bj1860621.
5
Impairment of effects of vasopressin on [1-14C]oleate metabolism in hepatocytes from obese (ob/ob) mice.肥胖（ob/ob）小鼠肝细胞中血管加压素对[1-14C]油酸代谢作用的损害。
Biochem J. 1981 Jul 15;198(1):239-42. doi: 10.1042/bj1980239.
6
Phosphatidylinositol metabolism in rat hepatocytes stimulated by vasopressin.血管加压素刺激下大鼠肝细胞中的磷脂酰肌醇代谢
Biochem J. 1981 Jan 15;194(1):155-65. doi: 10.1042/bj1940155.
7
Hormonal control of pyruvate dehydrogenase activity in rat liver.大鼠肝脏中丙酮酸脱氢酶活性的激素调控
Biochem J. 1984 Nov 15;224(1):181-6. doi: 10.1042/bj2240181.
8
Stimulation of hepatic lipogenesis and acetyl-coenzyme A carboxylase by vasopressin.血管加压素对肝脏脂肪生成和乙酰辅酶A羧化酶的刺激作用。
Biochem J. 1981 Sep 15;198(3):485-90. doi: 10.1042/bj1980485.
9
Resistance to hepatic action of vasopressin in genetically obese (ob/ob) mice.遗传性肥胖（ob/ob）小鼠对血管加压素肝脏作用的抵抗性。
Biochem J. 1976 Oct 15;160(1):23-8. doi: 10.1042/bj1600023.
10
Fatty acid synthesis in the perfused liver of adrenalectomized rats.肾上腺切除大鼠灌注肝脏中的脂肪酸合成
Biochem J. 1976 Jun 15;156(3):593-602. doi: 10.1042/bj1560593.
本文引用的文献
1
De novo synthesis of fatty acid in perfused rat liver as a determinant of plasma lipoprotein production.灌注大鼠肝脏中脂肪酸的从头合成作为血浆脂蛋白产生的决定因素。
Arch Biochem Biophys. 1967 Nov;122(2):362-9. doi: 10.1016/0003-9861(67)90206-8.
2
Perfusion in situ with tritium oxide to measure hepatic lipogenesis and lipid secretion. Normal and orotic acid-fed rats.用氧化氚原位灌注以测量肝脏脂肪生成和脂质分泌。正常大鼠和喂食乳清酸的大鼠。
J Biol Chem. 1966 Jun 25;241(12):2891-9.
3
Carbohydrate metabolism of the isolated perfused liver of normal and genetically obese--hyperglycaemic (ob-ob) mice.正常及遗传性肥胖-高血糖（ob-ob）小鼠离体灌注肝脏的碳水化合物代谢
Biochem J. 1971 Dec;125(3):773-80. doi: 10.1042/bj1250773.
4
3- -Hydroxysterol synthesis by the liver.肝脏合成3-β-羟基类固醇。
Arch Biochem Biophys. 1972 Jun;150(2):392-6. doi: 10.1016/0003-9861(72)90054-9.
5
Stimulation by vasopressin of glycogen breakdown and gluconeogenesis in the perfused rat liver.抗利尿激素对灌注大鼠肝脏中糖原分解和糖异生的刺激作用。
Biochem J. 1973 Nov;136(3):705-9. doi: 10.1042/bj1360705.
6
Interaction of mixed-function oxidation with biosynthetic processes. 2. Inhibition of lipogenesis by aminopyrine in perfused rat liver.混合功能氧化与生物合成过程的相互作用。2. 氨基比林对灌注大鼠肝脏脂肪生成的抑制作用。
Eur J Biochem. 1973 Sep 21;38(1):73-8. doi: 10.1111/j.1432-1033.1973.tb03035.x.
7
Fatty acid synthesis by liver perfused with deuterated and tritiated water.用氘水和氚水灌注肝脏进行脂肪酸合成。
Biochemistry. 1973 Jul 3;12(14):2619-24. doi: 10.1021/bi00738a011.
8
9
Synthesis of fatty acids in the perused mouse liver.在被研究的小鼠肝脏中脂肪酸的合成。
Biochem J. 1974 Sep;142(3):611-8. doi: 10.1042/bj1420611.
10
Hepatic action of vasopressin: lack of a role for adenosine-3',5'-cyclic monophosphate.
FEBS Lett. 1974 Oct 1;47(1):128-31. doi: 10.1016/0014-5793(74)80441-2.
Zotero 插件