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[碱性胰蛋白酶抑制剂对体外淋巴细胞母细胞转化的作用]

[Action of the basic trypsin inhibitor on lymphocyte blastic transformation in vitro].

作者信息

Camerini G, Menegatti E, Menghi P, Scorrano M

出版信息

Boll Ist Sieroter Milan. 1981 Jul 31;60(3):212-5.

PMID:7326096
Abstract

The effect of Basic-trypsin-inhibitor (BPTI) on the in vitro PHA-induced blastic transformation of lymphocytes is reported. Cultures of lymphocytes from healthy subjects were added with PHA, BPTI and PHA + BPTI; simple control-cultures were also performed. The blastic transformation was evaluated by morphologic method after 72 h incubation at 37 degrees C. The results are compared with Wilcoxon's test; it was observed that BPTI reduces the PHA-induced blastic transformation, but it has no effect on cultures without PHA. The hypothesis that BPTI inhibits only PHA-stimulated lymphocytes is suggested.

摘要

报道了碱性胰蛋白酶抑制剂（BPTI）对体外PHA诱导的淋巴细胞母细胞转化的影响。向来自健康受试者的淋巴细胞培养物中加入PHA、BPTI以及PHA + BPTI；同时也进行了单纯的对照培养。在37℃孵育72小时后，通过形态学方法评估母细胞转化情况。结果采用Wilcoxon检验进行比较；观察到BPTI可降低PHA诱导的母细胞转化，但对不含PHA的培养物无影响。由此提出BPTI仅抑制PHA刺激的淋巴细胞这一假说。

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