Fabris F, Randi M, Sbrojavacca R, Casonato A, Girolami A
Blut. 1981 Nov;43(5):279-85. doi: 10.1007/BF00320951.
ADP, adrenalin and collagen platelet aggregation studies were performed in 54 patients with elevated platelet counts: 38 patients showed primary thrombocythemia and 16 secondary thrombocytosis. Patients with primary thrombocythemia (78.7%) showed a decrease aggregation pattern while in patients with secondary thrombocytosis platelet aggregation response was entirely normal. An increase in platelet aggregation was obtained in four patients with primary thrombocythemia. The platelet aggregation response did not appear to be related to circulating platelet number. A relationship between increased platelet aggregation and the occurrence of thrombosis was demonstrated. Similarly, a correction between impaired platelet aggregation and bleeding was also present. These results emphasize the diagnostic value of platelet aggregation studies in patients with elevated platelet number.
对54例血小板计数升高的患者进行了二磷酸腺苷（ADP）、肾上腺素和胶原诱导的血小板聚集研究：38例患者表现为原发性血小板增多症，16例为继发性血小板增多症。原发性血小板增多症患者（78.7%）表现出聚集模式降低，而继发性血小板增多症患者的血小板聚集反应完全正常。4例原发性血小板增多症患者出现血小板聚集增加。血小板聚集反应似乎与循环血小板数量无关。证实了血小板聚集增加与血栓形成之间的关系。同样，血小板聚集受损与出血之间也存在关联。这些结果强调了血小板聚集研究对血小板计数升高患者的诊断价值。
