Shulman S, Harlin B, Davis P, Reyniak J V
Fertil Steril. 1978 Mar;29(3):309-13. doi: 10.1016/s0015-0282(16)43158-4.
A number of patients who have involuntary infertility show sperm antibodies in the blood serum, as detected by two quite different methods of spermagglutination. These techniques are the Kibrick method (gelatin agglutination test) and the F-D method (tube-slide agglutination test). By the former technique, the sera of 18% of women and 9% of men from infertile couples were found to be positive; by the latter technique, the sera of 15% of women and 5% of men were positive. Such cases are termed "immunologic infertility." In an effort to develop new methods for the treatment of infertility, two procedures were explored. One is a sperm washing insemination method in which fresh semen from a man with the antibody is centrifuged, resuspended in an albumin solution, and then used for insemination. The second is an immunosuppression method, using methylprednisolone at a dose of 96 mg/day for 7 days. A striking decrease in antibody level was seen in some cases, with ensuing pregnancy. The success rates for these methods have been of the order of 14% to 22%.
许多患有非自愿性不育症的患者血清中存在精子抗体，这是通过两种截然不同的精子凝集方法检测到的。这些技术是基布里克方法（明胶凝集试验）和F - D方法（试管 - 玻片凝集试验）。通过前一种技术，发现不育夫妇中18%的女性和9%的男性血清呈阳性；通过后一种技术，15%的女性和5%的男性血清呈阳性。此类病例被称为“免疫性不育”。为了开发治疗不育症的新方法，探索了两种程序。一种是精子洗涤授精方法，即对有抗体男性的新鲜精液进行离心，重悬于白蛋白溶液中，然后用于授精。第二种是免疫抑制方法，使用甲基强的松龙，剂量为96毫克/天，持续7天。在一些病例中观察到抗体水平显著下降，随后怀孕。这些方法的成功率约为14%至22%。
