Wender M, Adamczewska-Goncerzewicz Z, Goncerzewicz A, Pankrac J, Talkowska D
Exp Pathol. 1981;20(1):64-7. doi: 10.1016/s0232-1513(81)80012-6.
The investigations were performed on oligodendroglial cells isolated from the cerebral white matter of Wistar rats treated intravenously with a 3% solution of MNU at a dose of 60 mg/kg body weight. The oligodendroglial fraction showed a decrease of the sphingomyelin, phosphatidylserine and phosphoinositides content. The observed changes correlated with alterations of the lipid spectrum found in the myelin fraction of MNU intoxicated rats. This would indicate that MNU acting in the central nervous system affects in a similar way the lipid metabolism of both components of the oligodendroglia-myelin system.
对从经静脉注射60mg/kg体重的3%甲基亚硝基脲（MNU）溶液处理的Wistar大鼠脑白质中分离出的少突胶质细胞进行了研究。少突胶质细胞部分显示鞘磷脂、磷脂酰丝氨酸和磷酸肌醇含量降低。观察到的变化与MNU中毒大鼠髓鞘部分的脂质谱改变相关。这表明MNU作用于中枢神经系统时，以类似方式影响少突胶质细胞-髓鞘系统两个组成部分的脂质代谢。
