Mutchinick O, Ruz L, Gonsebatt M E, Mauleón P, Lisker R, García G
Hum Genet. 1981;59(2):137-40. doi: 10.1007/BF00293063.
Induced and spontaneous structural chromosome aberrations (SCA) were studied in a child accidentally radiated with a high dose of 192Ir, and in three sibs with Fanconi's anemia, analyzing by separate first division metaphases (FDM) and second division metaphases (SDM). The results showed that the number of SCA, number of cells with aberrations, and SCA per cell were markedly higher in FDM in all patients. Furthermore, for some type of structural changes like dicentric chromosomes and chromatid interchanges, the differences were particularly striking. The importance of ascertaining FDM identified with proper techniques, for the study of the clastogenic effect of environmental agents and some aspects related to the differences in cytogenetic features found in diverse tissues in Fanconi's anemia are discussed.
对一名意外受到高剂量¹⁹²铱辐射的儿童以及三名患有范可尼贫血的同胞进行了诱导性和自发性染色体结构畸变（SCA）研究，通过单独的第一次分裂中期（FDM）和第二次分裂中期（SDM）进行分析。结果显示，所有患者的FDM中SCA数量、有畸变的细胞数量以及每个细胞的SCA数量均显著更高。此外，对于某些类型的结构变化，如双着丝粒染色体和染色单体互换，差异尤为显著。本文讨论了采用适当技术确定FDM对于研究环境因素的致断裂效应以及范可尼贫血不同组织中细胞遗传学特征差异相关某些方面的重要性。
