Bergmann D G, Wolff D A
Intervirology. 1981;16(2):61-70. doi: 10.1159/000149249.
The production and release of R-type virus-like particles (VLP) was studied in several Syrian hamster cell lines. Most but not all hamster cell lines contain detectable levels of R-type VLP. However, only BHK-21 clone F (CF) cells would release the VLP into culture fluids. Treatment with dexamethasone enhanced to a limited extent the production and release of VLP from BHK-21 CF cells. Actinomycin D inhibited the production and release of R-type VLP in hamster cells, suggesting that some transcription from DNA is necessary for VLP production. Furthermore, 5-iododeoxyuridine induced the production of R-type VLP in Syrian hamster embryo cells. These results suggest that R-type VLP are endogenous to Syrian hamsters.
在几种叙利亚仓鼠细胞系中研究了R型病毒样颗粒（VLP）的产生和释放。大多数但并非所有的仓鼠细胞系都含有可检测水平的R型VLP。然而，只有BHK - 21克隆F（CF）细胞会将VLP释放到培养液中。地塞米松处理在一定程度上增强了BHK - 21 CF细胞中VLP的产生和释放。放线菌素D抑制仓鼠细胞中R型VLP的产生和释放，这表明VLP产生需要一些DNA转录。此外，5 - 碘脱氧尿苷诱导叙利亚仓鼠胚胎细胞产生R型VLP。这些结果表明R型VLP是叙利亚仓鼠内源性的。
