A rapid and sensitive method for the determination of phenazone (antipyrine) using gas-liquid-chromatography with nitrogen detection.

A simple and rapid method for the quantitative determination of antipyrine, using gas-liquid-chromatography with nitrogen detection, is described. Only one extraction step is needed, the recovery is 91.2% and the precision varies between 3.14--1.96%. The lower limit of quantitative assay reached 0.1 mg/l plasma. During routine handling the method was easy, quick and cheap.