Fackler K, Klein L, Hiltner A
J Microsc. 1981 Dec;124(Pt 3):305-11. doi: 10.1111/j.1365-2818.1981.tb02494.x.
The polarizing optical microscope has been used to observe morphologically the effect of stress on rat and bovine intestine. Collagen fibres about 6 micrometers in diameter were found to be biaxially oriented at approximately +30 degrees and -30 degrees to the longitudinal direction. The fibres are arranged in layers with the fibres in each layer densely packed in parallel undulating arrays. The undulations give rise to the extinction pattern observed in the polarizing optical microscope. The initial response to stress is straightening of the fibres. Gradual straightening of the fibres is related to the increasing stiffness of the tissue observed in the stress--strain relationship. Once the fibres ares straightened, the biaxial orientation of the fibres produces higher strength in the longitudinal direction than in the transverse direction. This organization of intestinal collagen fibres has not been reported previously and is not observed in other biaxial tissues such as skin and aorta. Thus, intestine is a unique tissue for studying the relationship of mechanical behaviour to structure and organization of collagen.
偏振光学显微镜已被用于从形态学上观察应力对大鼠和牛肠道的影响。发现直径约6微米的胶原纤维以与纵向方向大约呈+30度和-30度的双轴取向排列。这些纤维分层排列，每层中的纤维紧密排列成平行的波浪状阵列。这些起伏导致了在偏振光学显微镜下观察到的消光图案。对应力的初始反应是纤维变直。纤维的逐渐变直与应力-应变关系中观察到的组织刚度增加有关。一旦纤维变直，纤维的双轴取向在纵向方向上产生的强度高于横向方向。肠道胶原纤维的这种组织方式以前尚未见报道，在皮肤和主动脉等其他双轴组织中也未观察到。因此，肠道是研究胶原的力学行为与结构和组织关系的独特组织。
