Sunano S, Miyazaki E
Jpn J Physiol. 1981;31(4):445-56. doi: 10.2170/jjphysiol.31.445.
The effects of temperature and metabolic inhibitors on short tetanus contraction of vas deferens were studied. The contraction height increased by lowering temperature from 35 degrees C, and decreased with a decrease in temperature below 25 degrees C. The maximum speed of contraction and relaxation decreased by lowering the temperature, showing a transition of Q10 values at 25 degrees C. The Q10 value for the maximum speed of contraction was 1.7 between 35 to 25 degrees C, and 5.3 between 25 to 10 degrees C. The Q10 value for the maximum speed of relaxation was 1.9 between 35 and 25 degrees C, and 13.0 between 25 and 15 degrees C. The time to peak tension and to half relaxation increased by lowering temperature. The Q10 values also showed a transition at 25 degrees C. The Q10 value for the time to peak tension was -2.5 between 35 and 25 degrees C, and -5.0 between 25 to 5 degrees C. The Q10 value for the time to half maximum relaxation was -3.1 between 35 and 25 degrees C, and -5.7 between 25 and 5 degrees C. NaN3 and KCN and DNP inhibited the contraction. However, time to peak tension and half maximum relaxation time were not altered. Although the maximum speed of contraction and relaxation decreased, this was caused only by the reduction in peak tension. O2-free or glucose-free treatment caused only a slight decrease in peak tension. Neither time to peak tension nor half maximum relaxation time was altered. The differences between the effects of temperature and metabolic inhibition are discussed.
研究了温度和代谢抑制剂对输精管短强直收缩的影响。从35℃降低温度时，收缩高度增加，而温度降至25℃以下时收缩高度降低。收缩和舒张的最大速度随温度降低而下降，在25℃时Q10值出现转变。收缩最大速度的Q10值在35至25℃之间为1.7，在25至10℃之间为5.3。舒张最大速度的Q10值在35至25℃之间为1.9，在25至15℃之间为13.0。达到峰值张力的时间和达到半舒张的时间随温度降低而增加。Q10值在25℃时也出现转变。达到峰值张力时间的Q10值在35至25℃之间为 -2.5，在25至5℃之间为 -5.0。达到半最大舒张时间的Q10值在35至25℃之间为 -3.1，在25至5℃之间为 -5.7。NaN3、KCN和DNP抑制收缩。然而，达到峰值张力的时间和半最大舒张时间未改变。虽然收缩和舒张的最大速度降低，但这仅是由峰值张力的降低引起的。无氧或无葡萄糖处理仅使峰值张力略有降低。达到峰值张力的时间和半最大舒张时间均未改变。讨论了温度和代谢抑制作用之间的差异。
