Anuras S, Chien S M, Christensen J
Am J Physiol. 1980 Sep;239(3):G173-6. doi: 10.1152/ajpgi.1980.239.3.G173.
Strips of colon muscle (1 x 10 cm) were exposed to alterations of temperature, to 2,4-dinitrophenol, and were deprived of O2. Cooling reduced slow-wave frequency in proximal colon from 5.2 at 37 degrees C to 3.9, 2.7, 1.2 and 0.5 cycle/min at 34, 30, 25, and 20 degrees C, respectively; all changes were significant (P < 0.05). Heating also reduced slow-wave frequency in proximal colon from 5.2 at 37 degrees C to 5.1, 4.8 (P < 0.05), and 3.3 (P < 0.05) cycle/min at 39, 41, and 43 degrees C, respectively. Hypoxia reduced slow-wave frequency from 4.6 at 95% O2 to 2.8 cycle/min at 0% O2 (P < 0.05). 2,4-Dinitrophenol (10(-4) M) reduced frequency from 5.3 to 2.7 cycle/min (P < 0.05). The results of studies of distal colon were similar. In distal colon cooling reduced the time occupied by migrating spike bursts from 20.7% at 37 degrees C to 11.1% at 25 degrees C, and 7.9% at 20 degrees C (P < 0.05). Hypoxia also reduced the time occupied by migrating spike bursts from 16.7% at 95% O2 to 5.9% at 0% O2 (P < 0.05).
将结肠肌肉条（1×10厘米）暴露于温度变化、2,4-二硝基苯酚中，并使其缺氧。降温使近端结肠的慢波频率从37℃时的5.2次/分钟分别降至34℃时的3.9次/分钟、30℃时的2.7次/分钟、25℃时的1.2次/分钟和20℃时的0.5次/分钟；所有变化均具有显著性（P<0.05）。升温也使近端结肠的慢波频率从37℃时的5.2次/分钟分别降至39℃时的5.1次/分钟、41℃时的4.8次/分钟（P<0.05）和43℃时的3.3次/分钟（P<0.05）。缺氧使慢波频率从95%氧气条件下的4.6次/分钟降至0%氧气条件下的2.8次/分钟（P<0.05）。2,4-二硝基苯酚（10⁻⁴M）使频率从5.3次/分钟降至2.7次/分钟（P<0.05）。远端结肠的研究结果相似。在远端结肠，降温使移行性峰电位爆发所占时间从37℃时的20.7%降至25℃时的11.1%和20℃时的7.9%（P<0.05）。缺氧也使移行性峰电位爆发所占时间从95%氧气条件下的16.7%降至0%氧气条件下的5.9%（P<0.05）。
