Vilageliu J, Arañó A, Bruseghini L
Methods Find Exp Clin Pharmacol. 1981 Sep-Oct;3(5):279-81.
A method is described for obtaining endothelial lesions in the aorta by implanting polyethylene catheters in the aorta of rats for two days. Three types of lesions were observed and were quantified by measuring their lengths: (a) the simple disendothelization (b) raised lesions, and (c) tunnel lesions. The effect of a number of antiplatelet drugs on these types of lesions was investigated, and it was observed that these are particularly active in inhibiting tunnel lesions. Using this method, endothelial lesions can be obtained in a short period of time. Moreover, a large number of results can be obtained rapidly, which is important in these types of experiments due to the high dispersion obtained.
描述了一种通过将聚乙烯导管植入大鼠主动脉两天来在主动脉中获得内皮损伤的方法。观察到三种类型的损伤，并通过测量其长度进行量化：(a) 单纯去内皮化；(b) 隆起性损伤；(c) 隧道性损伤。研究了多种抗血小板药物对这些类型损伤的影响，观察到它们在抑制隧道性损伤方面特别有效。使用这种方法，可以在短时间内获得内皮损伤。此外，可以迅速获得大量结果，由于在这类实验中存在高度离散性，这一点很重要。
