Hartmann V, Magnussen H, Holle J P, Schüler E
Thorax. 1981 Oct;36(10):737-40. doi: 10.1136/thx.36.10.737.
Although histamine plays an important role in the pathophysiology of asthma through stimulation of H1 receptors, H1 antagonists are of only limited use in this disease when given orally. In order to investigate the pharmacological response to a specific H1 antagonist administered by different routes, we measured the effect of inhaled clemastine on airway responsiveness to histamine aerosol and compared the results with those after oral and intravenous administration in normal and asthmatic subjects. Inhalation of 0.6 mg clemastine provided significant protection without side effects and was comparable to intravenous administration of 1.0 mg in both groups. In normal subjects 2.0 mg clemastine orally was significantly less effective than the two other routes of administration whereas in asthmatics an enhanced reaction to histamine was observed.
尽管组胺通过刺激H1受体在哮喘的病理生理学中发挥重要作用，但口服H1拮抗剂在该疾病中的应用有限。为了研究不同给药途径给予特定H1拮抗剂的药理反应，我们测量了吸入氯马斯汀对组胺气雾剂气道反应性的影响，并将结果与正常人和哮喘患者口服及静脉给药后的结果进行比较。吸入0.6mg氯马斯汀可提供显著的保护作用且无副作用，在两组中与静脉注射1.0mg相当。在正常受试者中，口服2.0mg氯马斯汀的效果明显低于其他两种给药途径，而在哮喘患者中观察到对组胺的反应增强。
