Szczeklik A, Serwonska M
Thorax. 1979 Oct;34(5):654-7. doi: 10.1136/thx.34.5.654.
An H1-receptor blocking antihistamine, clemastine, taken before aspirin gave complete or partial protection against flushing, rhinorrhea, cough, and headache in ten asthmatic patients with idiosyncrasy to aspirin. In five of the ten patients aspirin-precipitated bronchoconstriction was also reduced or prevented after pretreatment with clemastine. Thus histamine appears to play a part in the production of most non-respiratory symptoms occurring after aspirin ingestion in intolerant patients with asthma. Bronchial reactions might depend partly on histamine and partly on the action of other spasmogens. It is suggested that inhibition of prostaglandins of the E series by aspirin-like drugs plays a crucial part in the release of histamine from tissue stores in aspirin-sensitive asthmatic patients. Clemastine might be of use in the treatment of acute reactions to aspirin.
一种H1受体阻断抗组胺药氯马斯汀，在阿司匹林给药前服用，可使10例对阿司匹林过敏的哮喘患者的面部潮红、鼻漏、咳嗽和头痛得到完全或部分缓解。在这10名患者中的5名中，氯马斯汀预处理后，阿司匹林诱发的支气管收缩也有所减轻或得到预防。因此，组胺似乎在不耐受性哮喘患者摄入阿司匹林后出现的大多数非呼吸道症状的产生中起作用。支气管反应可能部分取决于组胺，部分取决于其他痉挛原的作用。有人认为，阿司匹林样药物对E系列前列腺素的抑制在阿司匹林敏感哮喘患者的组胺从组织储存中释放过程中起关键作用。氯马斯汀可能对治疗阿司匹林急性反应有用。
