Ataullakhanov F I, Vitvitsky V M, Zhabotinsky A M, Pichugin A V, Kholodenko B N, Ehrlich L I
Acta Biol Med Ger. 1981;40(7-8):991-7.
The mathematical modelling of human erythrocyte energy metabolism has shown that stabilization of ATP concentration can be achieved if the curve representing the relation between glycolysis rate and ATP concentration (glycolysis characteristic) is bell-shaped with steeply descending part at physiologically normal ATP concentration. The glycolysis characteristic of human erythrocytes has been obtained experimentally. In erythrocytes of different donors the glycolysis characteristics are greatly different quantitatively, but have qualitatively similar bel-like shape with steeply descending part at physiologically normal ATP concentration. This characteristics can be made coincident for all donors if they are plotted in relative units taking for 100% the physiologically normal values of glycolysis rate and ATP for every individual donor. The coincidence of the normalized erythrocyte glycolysis characteristics for different donors can be achieved in the mathematical model of erythrocyte energy metabolism under the assumption that the phosphofructokinase rate depends effectively on the relation of ATP to adenylate pool and the total erythrocyte ATPase is strongly inhibited by AMP.
人体红细胞能量代谢的数学模型表明，如果代表糖酵解速率与ATP浓度之间关系的曲线（糖酵解特征曲线）呈钟形，且在生理正常ATP浓度下有陡峭下降部分，那么就可以实现ATP浓度的稳定。人体红细胞的糖酵解特征已通过实验获得。在不同供体的红细胞中，糖酵解特征在数量上有很大差异，但在质量上具有相似的钟形，在生理正常ATP浓度下有陡峭下降部分。如果以每个个体供体的糖酵解速率和ATP的生理正常值为100%，将这些特征以相对单位绘制，那么所有供体的这些特征就可以重合。在红细胞能量代谢的数学模型中，假设磷酸果糖激酶速率有效地依赖于ATP与腺苷酸池的关系，并且红细胞总ATP酶受到AMP的强烈抑制，就可以实现不同供体标准化红细胞糖酵解特征的重合。
