Feldman B F, Kaneko J J, Farver T B
Am J Vet Res. 1981 Jul;42(7):1109-13.
To characterize the erythroid homeostatic defect in canine inflammatory states, a single dose of Freund's complete adjuvant was injected subcutaneously to simulate naturally occurring infection and inflammation. After a latent period of 5 to 8 days, a generalized noninfectious inflammatory process was observed, followed by abscessation and drainage. This was accompanied by a modest anemia which decreased from base-line values by as much as 30%. In addition, a disordered iron metabolism was evidenced by depressed serum iron concentrations, total iron binding capacity (transferrin), percentage saturation of transferrin, and decreased numbers of bone marrow sideroblasts. Free RBC protoporphyrin concentrations were increased, as were serum copper, zinc, and ceruloplasmin. Bone marrow reticuloendothelial iron and hepatic nonheme iron were increased. Bone marrow myeloid-erythroid ratios were depressed. Throughout the course of the inflammatory period, the anemia remained normocytic and normochromic. A significant reticulocyte response was not observed.
为了描述犬类炎症状态下红系稳态缺陷的特征，皮下注射单剂量弗氏完全佐剂以模拟自然发生的感染和炎症。在5至8天的潜伏期后，观察到全身性非感染性炎症过程，随后出现脓肿形成和引流。这伴随着轻度贫血，血红蛋白水平比基线值降低了多达30%。此外，血清铁浓度、总铁结合力（转铁蛋白）、转铁蛋白饱和度百分比降低以及骨髓铁粒幼细胞数量减少，证明铁代谢紊乱。游离红细胞原卟啉浓度升高，血清铜、锌和铜蓝蛋白也升高。骨髓网状内皮铁和肝脏非血红素铁增加。骨髓髓红比降低。在整个炎症期，贫血仍为正细胞正色素性。未观察到明显的网织红细胞反应。
