去甲丙咪嗪血浆浓度的测定：放射免疫测定法与气相色谱法的比较
Determination of nomifensine plasma concentrations: a comparison of radioimmunoassay and gas chromatography.
作者信息
McIntyre I M, Norman T R, Burrows G D, Maguire K P
出版信息
Br J Clin Pharmacol. 1981 Nov;12(5):691-4. doi: 10.1111/j.1365-2125.1981.tb01291.x.
Abstract
1 A gas-liquid chromatography (g.l.c.) method for measurement of the antidepressant nomifensine was developed and compared for precision, accuracy, sensitivity and convenience with radioimmunoassay (RIA). 2 No significant difference was found between the two techniques for unconjugated nomifensine (y = 1.07x = 2.7; r = 0.996) or total nomifensine (y = 1.;02x + 0.02; r = 0.999). 3 RIA proved more sensitive than g.l.c. (detection limit of RIA being 1 microgram/l and g.l.c. 5 micrograms/l). 4 RIA was found to be a more convenient technique (up to 50 samples per day with RIA, and 16 samples with g.l.c.).
摘要
- 开发了一种用于测定抗抑郁药诺米芬辛的气液色谱（g.l.c.）方法，并与放射免疫分析（RIA）在精密度、准确度、灵敏度和便利性方面进行了比较。2. 对于游离诺米芬辛（y = 1.07x - 2.7；r = 0.996）或总诺米芬辛（y = 1.02x + 0.02；r = 0.999），两种技术之间未发现显著差异。3. 放射免疫分析比气液色谱更灵敏（放射免疫分析的检测限为1微克/升，气液色谱为5微克/升）。4. 放射免疫分析被发现是一种更方便的技术（放射免疫分析每天最多可处理50个样品，气液色谱为16个样品）。
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本文引用的文献
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Automated high-resolution gas chromatographic analysis of psychotropic drugs in biological fluids using open-tubular glass capillary columns. I. Determination of nomifensine in human plasma.使用开管玻璃毛细管柱对生物流体中的精神药物进行自动高分辨率气相色谱分析。I. 人血浆中诺米芬辛的测定。
J Chromatogr. 1977 Jan 21;131:347-55. doi: 10.1016/s0021-9673(00)80951-6.
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Dermination of therapeutic levels of butriptyline in plasma by gas-liquid chromatography.用气相色谱法测定血浆中布替林的治疗浓度。 （注：原文中“Dermination”拼写错误，正确应为“Determination”）
J Chromatogr. 1977 Apr 11;134(2):524-8. doi: 10.1016/s0021-9673(00)88554-4.
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Metabolism of nomifensine in man and animal species.诺米芬辛在人和动物物种中的代谢。
Arzneimittelforschung. 1978;28(1):58-64.
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