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一种测定血浆中诺米芬辛的简单气相色谱法及其与其他现有技术的比较。

A simple gas chromatographic method for the determination of nomifensine in plasma and a comparison of the method with other available techniques.

作者信息

Chamberlain J, Hill H M

出版信息

Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):117S-121S. doi: 10.1111/j.1365-2125.1977.tb05737.x.

DOI:10.1111/j.1365-2125.1977.tb05737.x
PMID:911647
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1429139/
Abstract
  1. A rapid simple gas chromatographic technique for determining nomifensine in plasma is described. 2. Nomifensine is rapidly absorbed after oral administration to man. 3. Following a 100-mg dose, peak levels of an acid-labile conjugate of 2--3 microgram/ml are reached about 1.5 h after administration. 4. The conjugate is cleared with a half-life of between 1 and 2 hours.
摘要
  1. 本文描述了一种用于测定血浆中去甲丙咪嗪的快速简易气相色谱技术。2. 去甲丙咪嗪经口服给药后在人体内吸收迅速。3. 给予100毫克剂量后，给药后约1.5小时可达到2 - 3微克/毫升酸不稳定结合物的峰值水平。4. 该结合物的清除半衰期在1至2小时之间。

相似文献

1
A simple gas chromatographic method for the determination of nomifensine in plasma and a comparison of the method with other available techniques.一种测定血浆中诺米芬辛的简单气相色谱法及其与其他现有技术的比较。
Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):117S-121S. doi: 10.1111/j.1365-2125.1977.tb05737.x.
2
Determination of nomifensine plasma concentrations: a comparison of radioimmunoassay and gas chromatography.去甲丙咪嗪血浆浓度的测定：放射免疫测定法与气相色谱法的比较
Br J Clin Pharmacol. 1981 Nov;12(5):691-4. doi: 10.1111/j.1365-2125.1981.tb01291.x.
3
Determination of nomifensine in human serum. A comparison of high-performance liquid and gas--liquid chromatography.
J Chromatogr. 1983 Aug 12;276(1):85-92.
4
Determination of nomifensine in pharmaceutical formulations and simultaneous GLC determination of nomifensine and benzodiazepines in human plasma.药物制剂中去甲丙咪嗪的测定及人血浆中去甲丙咪嗪和苯二氮䓬类药物的气相色谱同步测定。
Farmaco Prat. 1984 Jul;39(7):222-32.
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Selective and sensitive high-performance liquid chromatographic assay for the metabolites of nomifensine in human plasma.人血浆中去甲丙咪嗪代谢物的选择性和灵敏的高效液相色谱测定法。
J Chromatogr. 1985 Jun 14;341(2):333-9. doi: 10.1016/s0378-4347(00)84046-3.
6
Determination of nomifensine by a sensitive radioimmunoassay.用灵敏放射免疫分析法测定去甲丙咪嗪。
Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):123S-127S. doi: 10.1111/j.1365-2125.1977.tb05738.x.
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Gas-liquid chromatographic determination of 4'-hydroxynomifensine in biological samples.
J Chromatogr. 1980 Apr 4;190(2):475-80. doi: 10.1016/s0021-9673(00)88257-6.
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First-pass metabolism of nomifensine in dogs.诺米芬辛在犬体内的首过代谢。
Eur J Drug Metab Pharmacokinet. 1985 Jan-Mar;10(1):21-5. doi: 10.1007/BF03189693.
9
Gas chromatographic method for the determination of nomifensine in human plasma.气相色谱法测定人血浆中去甲丙咪嗪的含量。
J Chromatogr. 1976 Jan 21;116(2):451-6. doi: 10.1016/s0021-9673(00)89916-1.
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In vitro stability of nomifensine in plasma.去甲丙咪嗪在血浆中的体外稳定性。
Clin Chem. 1981 Jan;27(1):203-4.

引用本文的文献

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A comparison of the pharmacodynamic profiles of nomifensine and amitriptyline in normal subjects.正常受试者中诺米芬辛与阿米替林药效学特征的比较。
Br J Clin Pharmacol. 1980 Mar;9(3):247-53. doi: 10.1111/j.1365-2125.1980.tb04834.x.
2
Pharmacokinetics of nomifensine after a single oral dose.单次口服给药后去甲丙咪嗪的药代动力学
Br J Clin Pharmacol. 1982 May;13(5):740-3. doi: 10.1111/j.1365-2125.1982.tb01449.x.
3
First-pass metabolism of nomifensine in dogs.诺米芬辛在犬体内的首过代谢。
Eur J Drug Metab Pharmacokinet. 1985 Jan-Mar;10(1):21-5. doi: 10.1007/BF03189693.
4
Nomifensine: A review of its pharmacological properties and therapeutic efficacy in depressive illness.诺米芬辛：其药理特性及对抑郁症治疗效果的综述
Drugs. 1979 Jul;18(1):1-24. doi: 10.2165/00003495-197918010-00001.

本文引用的文献

1
Gas chromatographic method for the determination of nomifensine in human plasma.气相色谱法测定人血浆中去甲丙咪嗪的含量。
J Chromatogr. 1976 Jan 21;116(2):451-6. doi: 10.1016/s0021-9673(00)89916-1.
2
Automated high-resolution gas chromatographic analysis of psychotropic drugs in biological fluids using open-tubular glass capillary columns. I. Determination of nomifensine in human plasma.使用开管玻璃毛细管柱对生物流体中的精神药物进行自动高分辨率气相色谱分析。I. 人血浆中诺米芬辛的测定。
J Chromatogr. 1977 Jan 21;131:347-55. doi: 10.1016/s0021-9673(00)80951-6.