一种测定血浆中诺米芬辛的简单气相色谱法及其与其他现有技术的比较。
A simple gas chromatographic method for the determination of nomifensine in plasma and a comparison of the method with other available techniques.
作者信息
Chamberlain J, Hill H M
出版信息
Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):117S-121S. doi: 10.1111/j.1365-2125.1977.tb05737.x.
Abstract
- A rapid simple gas chromatographic technique for determining nomifensine in plasma is described. 2. Nomifensine is rapidly absorbed after oral administration to man. 3. Following a 100-mg dose, peak levels of an acid-labile conjugate of 2--3 microgram/ml are reached about 1.5 h after administration. 4. The conjugate is cleared with a half-life of between 1 and 2 hours.
摘要
- 本文描述了一种用于测定血浆中去甲丙咪嗪的快速简易气相色谱技术。2. 去甲丙咪嗪经口服给药后在人体内吸收迅速。3. 给予100毫克剂量后，给药后约1.5小时可达到2 - 3微克/毫升酸不稳定结合物的峰值水平。4. 该结合物的清除半衰期在1至2小时之间。
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A simple gas chromatographic method for the determination of nomifensine in plasma and a comparison of the method with other available techniques.一种测定血浆中诺米芬辛的简单气相色谱法及其与其他现有技术的比较。
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本文引用的文献
1
Gas chromatographic method for the determination of nomifensine in human plasma.气相色谱法测定人血浆中去甲丙咪嗪的含量。
J Chromatogr. 1976 Jan 21;116(2):451-6. doi: 10.1016/s0021-9673(00)89916-1.
2
Automated high-resolution gas chromatographic analysis of psychotropic drugs in biological fluids using open-tubular glass capillary columns. I. Determination of nomifensine in human plasma.使用开管玻璃毛细管柱对生物流体中的精神药物进行自动高分辨率气相色谱分析。I. 人血浆中诺米芬辛的测定。
J Chromatogr. 1977 Jan 21;131:347-55. doi: 10.1016/s0021-9673(00)80951-6.
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