• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

新西兰白化兔经典(巴甫洛夫式)条件反射中的年龄相关变化。

Age-related changes in classical (Pavlovian) conditioning in the New Zealand albino rabbit.

作者信息

Powell D A, Buchanan S L, Hernandez L L

出版信息

Exp Aging Res. 1981 Winter;7(4):453-65. doi: 10.1080/03610738108259824.

DOI:10.1080/03610738108259824
PMID:7333339
Abstract

The groups of New Zealand albino rabbits of approximately six and forty months of age respectively were subjected to Pavlovian conditioning in which a 1216 Hz, 75 dB tone served as the conditioning stimulus and a brief paraorbital electric shock train served as the unconditioned stimulus. Eyeblink and heart rate responses were assessed. Older animals revealed acquisition deficits in the somatomotor eyelid conditioning task compared to the young animals: however, the magnitude of the concomitantly occurring heart rate change was greater in older than in younger animals. These age-related changes appeared to be enhanced in males and were unrelated to general activity differences, or to the unconditioned response to unpaired tones or electric shocks.

摘要

分别对大约6个月和40个月大的新西兰白化兔进行巴甫洛夫条件反射实验,其中1216赫兹、75分贝的音调作为条件刺激,短暂的眶旁电击串作为非条件刺激。评估眨眼和心率反应。与年轻动物相比,老年动物在躯体运动眼睑条件反射任务中表现出习得缺陷:然而,老年动物伴随出现的心率变化幅度大于年轻动物。这些与年龄相关的变化在雄性中似乎更为明显,并且与一般活动差异、对未配对音调或电击的非条件反应无关。

相似文献

1
Age-related changes in classical (Pavlovian) conditioning in the New Zealand albino rabbit.新西兰白化兔经典(巴甫洛夫式)条件反射中的年龄相关变化。
Exp Aging Res. 1981 Winter;7(4):453-65. doi: 10.1080/03610738108259824.
2
Mediodorsal thalamic lesions and Pavlovian conditioning of heart rate and eyeblink responses in the rabbit.
Behav Neurosci. 1990 Dec;104(6):912-8. doi: 10.1037//0735-7044.104.6.912.
3
Discriminative delay Pavlovian eyeblink conditioning in veterans with and without posttraumatic stress disorder.患有和未患有创伤后应激障碍的退伍军人的辨别延迟巴甫洛夫眨眼条件反射
J Anxiety Disord. 2008 Jun;22(5):809-23. doi: 10.1016/j.janxdis.2007.08.009. Epub 2007 Aug 30.
4
Cingulate cortex: its role in Pavlovian conditioning.
J Comp Physiol Psychol. 1982 Oct;96(5):755-74. doi: 10.1037/h0077925.
5
Differential and reversal Pavlovian conditioning in rabbits with mediodorsal thalamic lesions: assessment of heart rate and eyeblink responses.伴有丘脑内侧背核损伤的家兔的差异与逆向巴甫洛夫条件反射:心率和眨眼反应评估
Exp Brain Res. 1991;86(1):174-81. doi: 10.1007/BF00231051.
6
Lateral hypothalamic lesions: effects on Pavlovian cardiac and eyeblink conditioning in the rabbit.下丘脑外侧损伤:对兔巴甫洛夫式心脏和眨眼条件反射的影响。
Brain Res Bull. 1981 Feb;6(2):155-63. doi: 10.1016/s0361-9230(81)80041-x.
7
Air puff versus shock unconditioned stimuli in rabbit heart rate conditioning.
Physiol Behav. 1992 Jan;51(1):195-9. doi: 10.1016/0031-9384(92)90223-o.
8
Pavlovian heart rate and jaw movement conditioning in the rabbit: effects of medial prefrontal lesions.家兔的巴甫洛夫式心率和下颌运动条件反射:内侧前额叶损伤的影响。
Neurobiol Learn Mem. 1999 Mar;71(2):150-66. doi: 10.1006/nlme.1998.3870.
9
Age-related disruption of trace but not delay classical conditioning of the rabbit's nictitating membrane response.与年龄相关的痕迹性经典条件反射的破坏,但不影响家兔瞬膜反应的延迟性经典条件反射。
Behav Neurosci. 1985 Feb;99(1):88-96. doi: 10.1037//0735-7044.99.1.88.
10
Prefrontal control of trace eyeblink conditioning in rabbits (Oryctolagus cuniculus) II: effects of type of unconditioned stimulus (airpuff vs. periorbital shock) and unconditioned stimulus intensity.家兔(穴兔)痕迹性眨眼条件反射的前额叶控制II:非条件刺激类型(气吹与眶周电击)及非条件刺激强度的影响
Physiol Behav. 2009 Jan 8;96(1):67-72. doi: 10.1016/j.physbeh.2008.08.013. Epub 2008 Aug 24.

引用本文的文献

1
Insights into CNS ageing from animal models of senescence.从衰老动物模型看中枢神经系统老化。
Nat Rev Neurosci. 2012 May 10;13(6):435-45. doi: 10.1038/nrn3230.
2
Physiological and anatomical studies of associative learning: Convergence with learning studies of W.T. Greenough.关于联想学习的生理学和解剖学研究:与 W.T. Greenough 的学习研究的融合。
Dev Psychobiol. 2011 Jul;53(5):489-504. doi: 10.1002/dev.20554.
3
Effects of paradigm and inter-stimulus interval on age differences in eyeblink classical conditioning in rabbits.
范式和刺激间隔对兔眨眼经典条件反射年龄差异的影响。
Learn Mem. 2007 Apr 6;14(4):287-94. doi: 10.1101/lm.504107. Print 2007 Apr.
4
Eighteen-month-old Fischer 344 rats fed a spinach-enriched diet show improved delay classical eyeblink conditioning and reduced expression of tumor necrosis factor alpha (TNFalpha ) and TNFbeta in the cerebellum.喂食富含菠菜饮食的18个月大的Fischer 344大鼠在延迟经典眨眼条件反射方面表现出改善,并且小脑肿瘤坏死因子α(TNFα)和肿瘤坏死因子β(TNFβ)的表达降低。
J Neurosci. 2002 Jul 15;22(14):5813-6. doi: 10.1523/JNEUROSCI.22-14-05813.2002.
5
Nefiracetam (DM-9384): effect on eyeblink classical conditioning in older rabbits.奈非西坦(DM - 9384):对老年兔眨眼经典条件反射的影响
Psychopharmacology (Berl). 1994 Mar;114(2):200-8. doi: 10.1007/BF02244837.