Department of Psychology, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, USA.
Dev Psychobiol. 2011 Jul;53(5):489-504. doi: 10.1002/dev.20554.
The quest to understand how the brain is able to store information for later retrieval has been pursued by many scientists through the years. Although many have made very significant contributions to the field and our current understanding of the process, few have played as pivotal a role in advancing our understanding as William T. Greenough. The current report will utilize associative learning, a training paradigm that has greatly assisted in our understanding of memory consolidation, to demonstrate how findings emerging from the Greenough laboratory helped to not only shape our current understanding of learning induced anatomical plasticity, but to also launch future analyses into the molecular players involved in this process, especially the Fragile X Mental Retardation Protein.
多年来，许多科学家一直在探索大脑如何存储信息以备后用。尽管许多人对该领域做出了非常重大的贡献，并且我们目前对这一过程的理解也有所加深，但在推动我们对记忆巩固的理解方面，几乎没有人能像威廉·T·格林诺那样起到关键作用。本报告将利用联想学习，这一训练范例极大地帮助我们理解了记忆巩固，来展示格林诺实验室的研究结果不仅如何帮助我们塑造了目前对学习诱导的解剖可塑性的理解，而且还为这一过程中涉及的分子参与者，特别是脆性 X 智力迟钝蛋白的未来分析奠定了基础。
