Mocchetti I, De Angelis L, Racagni G
J Neurochem. 1981 Dec;37(6):1607-9. doi: 10.1111/j.1471-4159.1981.tb06334.x.
A specific and sensitive gas chromatographic-mass spectrometric assay for measurement of normetanephrine (NMN) in different rat brain regions is presented. The results show that hypothalamus contains the highest concentrations of the norepinephrine metabolite. An increase of NMN concentrations has been detected in animals killed by decapitation in comparison with microwave-irradiated rats. This finding has to be taken into consideration when NMN is measured in the brain in order to assess the functional activity of noradrenergic neurons.
本文介绍了一种用于测量不同大鼠脑区去甲肾上腺素（NMN）的特异性和灵敏的气相色谱 - 质谱分析法。结果表明，下丘脑含有最高浓度的去甲肾上腺素代谢物。与微波照射的大鼠相比，断头处死的动物中检测到NMN浓度增加。在测量脑中NMN以评估去甲肾上腺素能神经元的功能活性时，必须考虑这一发现。
