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Blockade by burimamide of the restorative effect of histamine in tetrodotoxin-treated heart preparations.布立马胺对组胺在河豚毒素处理的心脏制剂中的恢复作用的阻断。
Br J Pharmacol. 1976 Jun;57(2):247-9. doi: 10.1111/j.1476-5381.1976.tb07474.x.
2
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3
Effects of the H1-antagonist promethazine and the H2-antagonist burimamide on chronotropic, inotropic and coronary vascular responses to histamine in isolated perfused guinea-pig hearts.H1拮抗剂异丙嗪和H2拮抗剂布立马胺对离体灌注豚鼠心脏中组胺引起的变时性、变力性及冠状血管反应的影响。
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Occurrence of H2-receptors for histamine in the guinea-pig intestine.组胺H2受体在豚鼠肠道中的存在情况。
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Calcium antagonistic and antiarrhythmic actions of CPU-23, a substituted tetrahydroisoquinoline.CPU-23（一种取代的四氢异喹啉）的钙拮抗作用和抗心律失常作用。
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A histamine-induced decrease of action potential duration in cardiac muscle mediated by the H2 receptors.由H2受体介导的组胺引起的心肌动作电位时程缩短。
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本文引用的文献

1
Restoration effects of histamine on action potential in potassium-depolarized guinea-pig papillary muscle.组胺对低钾去极化豚鼠乳头肌动作电位的恢复作用
Arch Int Pharmacodyn Ther. 1973 Nov;206(1):113-20.
2
Differentiation of the transmembrane Na and Ca channels in mammalian cardiac fibres by the use of specific inhibitors.利用特异性抑制剂对哺乳动物心脏纤维中跨膜钠通道和钙通道进行区分。
Pflugers Arch. 1972;335(4):309-22. doi: 10.1007/BF00586221.
3
Histamine effects on cardiac contractility, phosphorylase and adenyl cyclase.组胺对心脏收缩性、磷酸化酶和腺苷酸环化酶的影响。
J Mol Cell Cardiol. 1972 Dec;4(6):611-24. doi: 10.1016/0022-2828(72)90115-0.
4
Definition and antagonism of histamine H 2 -receptors.组胺H2受体的定义与拮抗作用。
Nature. 1972 Apr 21;236(5347):385-90. doi: 10.1038/236385a0.
5
Effects of histamine and noradrenaline on contractile force of guinea-pig ventricular strips: antagonism by burimamide and metiamide.组胺和去甲肾上腺素对豚鼠心室肌条收缩力的影响：甲硫咪胺和甲氰咪胍的拮抗作用。
Agents Actions. 1974 Dec;4(5):314-9. doi: 10.1007/BF01964933.
6
Blockade by burimamide of the effects of histamine and histamine analogs on cardiac contractility, phosphorylase activation and cyclic adenosine monophosphate.布立马胺对组胺及组胺类似物在心脏收缩性、磷酸化酶激活和环磷酸腺苷方面作用的阻断。
J Pharmacol Exp Ther. 1974 Jan;188(1):180-8.

布立马胺对组胺在河豚毒素处理的心脏制剂中的恢复作用的阻断。

Blockade by burimamide of the restorative effect of histamine in tetrodotoxin-treated heart preparations.

作者信息

Ledda F, Mantelli L, Mugelli A

出版信息

Br J Pharmacol. 1976 Jun;57(2):247-9. doi: 10.1111/j.1476-5381.1976.tb07474.x.

DOI:10.1111/j.1476-5381.1976.tb07474.x
PMID:7335
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1667117/
Abstract

1 In isolated heart preparations in which fast sodium channels were blocked by tetrodotoxin (2-4 x 10(-5) M), excitability was restored by histamine (6 x 10(-6) M to 10(-5) M). 2 This effect was antagonized by EDTA (2 X 10(-6) M),D600 compound (0.5mug/ml) and the H2-receptor antagonist, burimamide(2 X 10(-4) M).

摘要
  1. 在分离的心脏标本中，快速钠通道被河豚毒素（2 - 4×10⁻⁵ M）阻断，组胺（6×10⁻⁶ M至10⁻⁵ M）可恢复其兴奋性。2. 这种效应被乙二胺四乙酸（2×10⁻⁶ M）、D600化合物（0.5μg/ml）和H₂受体拮抗剂布立马胺（2×10⁻⁴ M）所拮抗。