布立马胺对组胺在河豚毒素处理的心脏制剂中的恢复作用的阻断。
Blockade by burimamide of the restorative effect of histamine in tetrodotoxin-treated heart preparations.
作者信息
Ledda F, Mantelli L, Mugelli A
出版信息
Br J Pharmacol. 1976 Jun;57(2):247-9. doi: 10.1111/j.1476-5381.1976.tb07474.x.
Abstract
1 In isolated heart preparations in which fast sodium channels were blocked by tetrodotoxin (2-4 x 10(-5) M), excitability was restored by histamine (6 x 10(-6) M to 10(-5) M). 2 This effect was antagonized by EDTA (2 X 10(-6) M),D600 compound (0.5mug/ml) and the H2-receptor antagonist, burimamide(2 X 10(-4) M).
摘要
- 在分离的心脏标本中，快速钠通道被河豚毒素（2 - 4×10⁻⁵ M）阻断，组胺（6×10⁻⁶ M至10⁻⁵ M）可恢复其兴奋性。2. 这种效应被乙二胺四乙酸（2×10⁻⁶ M）、D600化合物（0.5μg/ml）和H₂受体拮抗剂布立马胺（2×10⁻⁴ M）所拮抗。
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本文引用的文献
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Arch Int Pharmacodyn Ther. 1973 Nov;206(1):113-20.
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Differentiation of the transmembrane Na and Ca channels in mammalian cardiac fibres by the use of specific inhibitors.利用特异性抑制剂对哺乳动物心脏纤维中跨膜钠通道和钙通道进行区分。
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Histamine effects on cardiac contractility, phosphorylase and adenyl cyclase.组胺对心脏收缩性、磷酸化酶和腺苷酸环化酶的影响。
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Nature. 1972 Apr 21;236(5347):385-90. doi: 10.1038/236385a0.
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