Haas G G, Sokoloski J E, Wolf D P
Am J Reprod Immunol (1980). 1980;1(1):40-3. doi: 10.1111/j.1600-0897.1980.tb00009.x.
A liquid-phase radioimmunoassay was used to quantitate sperm-associated IgG in a population of patients with unexplained infertility. Plasma IgG antisperm antibody activity was identified in a subpopulation of these patients. Using the human sperm/hamster egg assay, a unique functional test of human sperm penetrating capacity, we identified a subset of these positive patients whose plasma significantly and reproducibly inhibited penetration. This study implies that antigen-antibody reactions may prevent sperm responses that are critical to sperm-egg fusion.
采用液相放射免疫分析法对一群不明原因不孕症患者的精子相关IgG进行定量分析。在这些患者的一个亚群中检测到血浆IgG抗精子抗体活性。利用人精子/仓鼠卵试验（一种独特的人类精子穿透能力功能测试），我们在这些阳性患者中识别出一个亚组，其血浆能显著且可重复地抑制精子穿透。本研究表明，抗原 - 抗体反应可能会阻止对精卵融合至关重要的精子反应。
