Kent W C, Soulsby M E, Whitney J E
Artery. 1981;9(6):425-36.
The in vitro effect of 17 alpha-ethinylestradiol (E) and/or medroxy progesterone acetate (P) was determined on their abilities to alter conversion of glucose to lipid by porcine aorta. The combination of steroidal agents EP/HI (combination at high concentration) at a concentration of 9.5 X 10(-9) moles/ml caused a significant (p less than 0.01) reduction in 14C incorporation into total lipid. When the concentration of each hormone was reduced by one-half EP/LO (combination at low concentration) to give a final concentration of 4.8 X 10(-9) moles/ml the incorporation was also significantly reduced (p less than 0.05). The aforementioned reductions were subsequently found to be the result of depressed incorporation of the substrate glucose for the synthesis of phospholipid (PL), triacylglyceride (TG), a combined fraction of free cholesterol, diacylglyceride and free fatty acid (FC+DG+FFA), and cholesteryl ester (CE). The hormones individually had no effect on the incorporation of U14C-glucose into lipid. The study suggests that these oral contraceptives, when administered in pharmacological doses, can depress the conversion of glucose into arterial wall lipid.
研究了17α-乙炔雌二醇（E）和/或醋酸甲羟孕酮（P）对猪主动脉将葡萄糖转化为脂质能力的体外作用。甾体药物EP/HI（高浓度组合）在浓度为9.5×10⁻⁹摩尔/毫升时，导致掺入总脂质中的¹⁴C显著减少（p＜0.01）。当每种激素的浓度减半至EP/LO（低浓度组合），最终浓度为4.8×10⁻⁹摩尔/毫升时，掺入量也显著减少（p＜0.05）。随后发现，上述减少是由于用于合成磷脂（PL）、三酰甘油（TG）、游离胆固醇、二酰甘油和游离脂肪酸的组合部分（FC+DG+FFA）以及胆固醇酯（CE）的底物葡萄糖掺入减少所致。单独使用这些激素对¹⁴C-葡萄糖掺入脂质没有影响。该研究表明，这些口服避孕药以药理剂量给药时，可抑制葡萄糖向动脉壁脂质的转化。
