来自南棘蛇（Acanthophis antarcticus）毒液的一种短链神经毒素的氨基酸序列及游离巯基的位置。
The amino acid sequence and position of the free thiol group of a short-chain neurotoxin from common-death-adder (Acanthophis antarcticus) venom.
作者信息
Kim H S, Tamiya N
出版信息
Biochem J. 1981 Oct 1;199(1):211-8. doi: 10.1042/bj1990211.
Abstract
The amino acid sequence of a short-chain neurotoxin Acanthophis antarcticus c (toxin Aa c) from the venom of an Australian elapid snake, the common death adder (Acanthophis antarcticus, subfamily Acanthophiinae) was elucidated. Toxin Aa c is composed of 62 amino acid residues, including eight half-cystine residues and a cysteine residue. The amino acid sequence of toxin Aa c is homologous with those of other short-chain neurotoxins found in snakes of the family Elapidae, especially with those from snakes of the subfamily Hydrophiinae. The single cysteine residue was located in position 4. Toxin Aa c has a lethal dose (LD50) of 0.08 micrograms/g body weight of mouse on intramuscular injection.
摘要
对澳大利亚眼镜蛇科毒蛇——普通死亡蝰蛇（Acanthophis antarcticus，棘蝰亚科）毒液中的一种短链神经毒素南极棘蛇毒素c（毒素Aa c）的氨基酸序列进行了阐明。毒素Aa c由62个氨基酸残基组成，包括8个半胱氨酸残基和1个半胱氨酸残基。毒素Aa c的氨基酸序列与眼镜蛇科蛇类中发现的其他短链神经毒素的序列同源，尤其是与海蛇亚科蛇类的毒素序列同源。单个半胱氨酸残基位于第4位。毒素Aa c经肌肉注射对小鼠的致死剂量（LD50）为0.08微克/克体重。
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