Weiszfeiler J G, Karasseva V
Rev Infect Dis. 1981 Sep-Oct;3(5):1081-3. doi: 10.1093/clinids/3.5.1081.
A pathologic event in humans or animals that involves the participation of two or more species of mycobacteria may be designated as a mixed mycobacterial infection. In the majority of cases of such mixed infection, Mycobacterium tuberculosis is found with one of the atypical mycobacteria. The allergic and immune reactions produced by Mycobacterium simiae, Mycobacterium asiaticum, and Mycobacterium chelonei in guinea pigs was studied. Sensitins that were prepared from cultures of these microorganisms were species specific, producing intensive cutaneous reactions in the animals infected with these organisms. Animals that received atypical mycobacteria and were infected secondarily with bacille Calmette-Guérin (BCG) had a positive reaction to tuberculin H37Rv PPD-S, but the sensitivity of such animals to the atypical strains was not altered. The atypical strains studied have no immunogenic power against tuberculosis, and they reduced the immunizing power of BCG, probably by exerting an immunosuppressive effect.
涉及两种或更多种分枝杆菌参与的人类或动物病理事件可被称为混合分枝杆菌感染。在大多数此类混合感染病例中，结核分枝杆菌与一种非典型分枝杆菌同时存在。研究了猿分枝杆菌、亚洲分枝杆菌和龟分枝杆菌在豚鼠中产生的过敏和免疫反应。从这些微生物培养物中制备的致敏素具有种属特异性，在感染这些微生物的动物中产生强烈的皮肤反应。接受非典型分枝杆菌并继发感染卡介苗（BCG）的动物对结核菌素H37Rv PPD-S呈阳性反应，但此类动物对非典型菌株的敏感性未改变。所研究的非典型菌株对结核病没有免疫原性，它们可能通过发挥免疫抑制作用降低了BCG的免疫能力。
