Iablokova T B, Levi D T, Kartsag E, Lazaruk L M
Zh Mikrobiol Epidemiol Immunobiol. 1976 Jan(1):123-6.
A study was made of the specific sensitivity to tuberculin in the animals vaccinated with BCG in case of their additional sensitization with various atypical mycobacteria. The mentioned experimental study appeared to be necessary for the purpose of a more proper treatment of the epidemiological date referred to the sensitivity of man to tuberculin and sensitins against the background of mass BCG vaccination. Preliminary BCG vaccination of the animals with their subsequent infection with atypical mycobacteria altered the allergic response to the antigens from the mycobacteria increasing the response reactions not only to tuberculin, but also to sensitins from mycobacteria of the I--III groups by Runyon's classification, closely connected in antigenic respect with mycobacteria tuberculosis. Skin reactions to sensitins from the saprophytic mycobacteria which had in their composition much less common antigens with mycobacteria tuberculosis, remained at the low level. Sensitization with atypical mycobacteria of animals preliminarily vaccinated with BCG failed to cause significant influence on the production of immunity to the subsequent virulent infection with tuberculosis.
对接种卡介苗的动物在用各种非典型分枝杆菌进行额外致敏时对结核菌素的特异性敏感性进行了研究。鉴于在大规模卡介苗接种背景下，为了更恰当地处理有关人类对结核菌素和敏感素敏感性的流行病学数据，上述实验研究显得很有必要。先对动物进行卡介苗接种，随后使其感染非典型分枝杆菌，这改变了动物对分枝杆菌抗原的过敏反应，不仅增强了对结核菌素的反应，还增强了对鲁尼恩分类中I - III组分枝杆菌敏感素的反应，这些分枝杆菌在抗原方面与结核分枝杆菌密切相关。对腐生分枝杆菌敏感素的皮肤反应仍处于较低水平，腐生分枝杆菌与结核分枝杆菌的共同抗原要少得多。先用卡介苗接种动物，再用非典型分枝杆菌致敏，这对动物随后抵抗结核强毒感染的免疫产生没有显著影响。
