Intra-nasal distribution of aerosols with or without vibration.

Intra-nasal distribution of aerosol deposited with or without air flow vibration was investigated by the use of a cast of human nose. In order to analyze the effect of vibration on the particle deposition, the size distribution and the concentration of aerosol were simultaneously measured by an on-lined laser beam scattering particle counter. According to the experimental and the theoretical considerations, it was found that the vibration strongly affected on the motion of particles and then the aerosol particle was more widely and uniformly distributed in the nasal cavity by vibrating the air. This also caused the increasing of particle deposition efficiency and the changing the partial efficiency of each particle size in it. Judging from the above mentioned facts, it was considered that the vibration aerosol therapy would be an useful technique for nasal diseases as well as paranasal sinus diseases.