Belbeck L, Bowen B M, Jeu J, Richardson M
Can J Comp Med. 1981 Jul;45(3):299-303.
A subacute toxicity study on 99m Tc stannous glucoheptonate was performed with rats, dogs and rabbits, injected intravenously at ten to 100 times the human dose on a body weight basis. There were no abnormalities in the clinical status of any of the animals. No changes were found in urinalysis, blood chemistry or hematology in the rabbit nor in gross examination, renal histology or bone marrow smears in the rats and rabbits. Hepatic histology was also done. A focal area of necrosis in a liver of one rabbit that had been injected with 100 times the human dose was observed using light microscopy. Examination by electron microscopy in another group of rats and rabbits was prompted by the observation of that lesion. This revealed vacuolated and dilated smooth endoplasmic reticulum and degranulated and vesiculated rough endoplasmic reticulum in all the test livers. X-ray microanalysis indicates that the ultrastructural changes are linked to the deposition of tin.
用大鼠、狗和兔子进行了一项关于99m锝葡庚糖酸亚锡的亚急性毒性研究，按体重计算静脉注射的剂量为人类剂量的10至100倍。所有动物的临床状态均无异常。兔子的尿液分析、血液化学或血液学检查未发现变化，大鼠和兔子的大体检查、肾脏组织学或骨髓涂片也未发现变化。还进行了肝脏组织学检查。在一只注射了100倍人类剂量的兔子的肝脏中，通过光学显微镜观察到一个局灶性坏死区域。对该病变的观察促使在另一组大鼠和兔子中进行电子显微镜检查。这显示所有受试肝脏中滑面内质网空泡化和扩张，粗面内质网脱颗粒和形成小泡。X射线微量分析表明，超微结构变化与锡的沉积有关。
