Assis M L, Neto J B, Souza J E, Caldeira-de-Araújo A, Bernardo-Filho M
Departamento de Biofísica e Biometria, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Cancer Lett. 1998 Aug 14;130(1-2):127-31. doi: 10.1016/s0304-3835(98)00125-6.
Stannous dichloride is used as a reducing agent in the preparation of technetium-99m radiopharmaceuticals. We decided to evaluate the genotoxic potential of the tin (II)-glucoheptonate complex in the kit using a tester strain of Escherichia coli AB1157. Our results show that tin (II) chloride and the tin (II)-glucoheptonate complex exert a genotoxic effect in this system. While the genotoxic effect disappeared when the glucoheptonate concentration was increased, the glucoheptonate did not protect the cultures from the damaging effects of hydrogen peroxide. The ability of glucoheptonate to protect cultures from tin (II)-induced damage can be explained on the basis of its metal chelating properties.
二氯化锡在制备锝-99m放射性药物时用作还原剂。我们决定使用大肠杆菌AB1157测试菌株评估试剂盒中锡（II）-葡庚糖酸盐复合物的遗传毒性潜力。我们的结果表明，氯化锡（II）和锡（II）-葡庚糖酸盐复合物在该系统中发挥遗传毒性作用。虽然当葡庚糖酸盐浓度增加时遗传毒性作用消失，但葡庚糖酸盐并不能保护培养物免受过氧化氢的破坏作用。葡庚糖酸盐保护培养物免受锡（II）诱导损伤的能力可基于其金属螯合特性来解释。
