Ravindranath V, Chandrasekhara N
Toxicology. 1981;22(4):337-44. doi: 10.1016/0300-483x(81)90027-5.
Radioactivity was detectable in blood, liver and kidney following dosage with 400, 80 or 10 mg of [3H]curcumin. The major route of elimination of the label was the feces; the urinary excretion of the label was very low regardless of the dose. At the lower doses of 80 mg and 10 mg of [3H]-curcumin, most of the label was excreted within 72 h, while with 400 mg, considerable amounts of the label was present in the tissues 12 days after dosage. The percentage of curcumin absorbed (60-66% of the given dose) remained constant regardless of the dose administered.
给予400、80或10毫克[3H]姜黄素后，在血液、肝脏和肾脏中可检测到放射性。标记物的主要消除途径是粪便；无论剂量如何，标记物的尿液排泄量都非常低。在较低剂量的80毫克和10毫克[3H]姜黄素时，大部分标记物在72小时内排出，而给予400毫克时，给药后12天组织中仍存在相当数量的标记物。无论给药剂量如何，吸收的姜黄素百分比（占给药剂量的60-66%）保持恒定。
