Holder G M, Plummer J L, Ryan A J
Xenobiotica. 1978 Dec;8(12):761-8. doi: 10.3109/00498257809069589.
Curcumin labelled with deuterium and tritium was prepared. Oral and intraperitoneal doses of [3H]curcumin led to the faecal excretion of most of the radioactivity. 2. Intravenous and intraperitoneal doses of [3H]curcumin were well excreted in the bile of cannulated rats. 3. The major biliary metabolites were glucuronides of tetrahydrocurcumin and hexahydrocurcumin. A minor biliary metabolite was dihydroferulic acid together with traces of ferulic acid. Metabolites were identified using chemical ionization mass spectrometry.
制备了用氘和氚标记的姜黄素。口服和腹腔注射剂量的[3H]姜黄素导致大部分放射性物质经粪便排出。2. 静脉注射和腹腔注射剂量的[3H]姜黄素在插管大鼠的胆汁中排泄良好。3. 主要的胆汁代谢产物是四氢姜黄素和六氢姜黄素的葡糖醛酸苷。一种次要的胆汁代谢产物是二氢阿魏酸以及痕量的阿魏酸。使用化学电离质谱法鉴定代谢产物。
