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[一名接受血液透析的女性发生自发性骨折,可能与口服铝凝胶有关(作者译)]

[Spontaneous fracture in a hemodialyzed woman probably associated with the oral intake of aluminium gel (author's transl)].

作者信息

Fournier G, Gaillard J L, Bourdon R, Drüeke T

出版信息

Nephrologie. 1981;2(1):23-6.

PMID:7345373
Abstract

A hemodialyzed woman with radiologically and histologically proven osteomalacia presents a spontaneous fracture that is associated with aluminium intoxication. The hyperalbuminemia (16,6 mumol/1) was not caused by the aluminium contained in the dialysate fluid but by oral ingestion of aluminium gel in a patient presenting hyperabsorption of this metal. Increased absorption could be demonstrated by oral administration of aluminium hydroxide (2 x 12 g A1 (OH)3 spread over 48 hrs) whereas the same test failed to reveal hyperabsorption in two other hemodialyzed patients. The precise mechanism of increased absorption of aluminium is not known. It is concluded that increased digestive absorption of aluminium should be investigated in patients with kidney failure treated with aluminium gel and presenting high blood levels of this metal.

摘要

一名经放射学和组织学证实患有骨软化症的血液透析女性出现了与铝中毒相关的自发性骨折。高铝血症(16.6 μmol/L)并非由透析液中的铝所致,而是由于该金属吸收过多的患者口服了铝凝胶。口服氢氧化铝(分48小时服用2次,每次12 g Al(OH)₃)可证实铝吸收增加,而相同检测未能在另外两名血液透析患者中发现铝吸收过多。铝吸收增加的确切机制尚不清楚。结论是,对于接受铝凝胶治疗且血铝水平高的肾衰竭患者,应研究其铝消化吸收增加的情况。

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