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60岁之后的癫痫发作(作者译)

[Seizures after the age of sixty (author's transl)].

作者信息

Vercelletto P, Gastaut J L

出版信息

Rev Electroencephalogr Neurophysiol Clin. 1981 Dec;11(3-4):537-44. doi: 10.1016/s0370-4475(81)80098-6.

Abstract

Three percent of epileptic patients have their first seizure after the age of 60. More than at other ages, the real nature of such fits is very difficult to assert. Most of the reversible attacks occurring at this age are not of grave nature, syncopes are much more frequent. Some semeiological aspects are discussed. Focal seizures are more frequent after the age of 60. Absence status may be the first epileptic symptom in some rare cases (almost all of them being women). 100 patients whose ages ranged from 60 to 83 years, were examined after their first seizure and aetiological problems were examined. The following topics are discussed:--The possible onset of a primary epilepsy, extremely rare at that age;--The incidence of neoplasms, not exceeding 10% for patients whose late onset epilepsy is still an isolated symptom, and who have not been selected from specialized neurological or neurosurgical hospital departments;--The role of vascular epilepsy; in a very few cases, but of great practical interest, the epilepsy may announce a cerebrovascular accident which will occur later. It is, however, difficult to specify the vascular origin of a certain number of temporary unexplained late onset epilepsies. Some other aetiological factors are taken into account: antecedents of trauma, alcoholism, and dementia. The authors agree that in 50% of the cases the aetiology is not obvious. In this group of unknown aetiology it seemed interesting to isolate the following electroclinical form;--Epilepsy grand mal, with apparently generalized seizures; no special pathological antecedents; the neuropsychological and neurological examinations are normal, showing no intellectual disorders; the EEG generally shows slight modifications: quick rhythms, some sharp waves; a global cerebral atrophy is seen by the scanner. Such patients have been called victims of 'secondary late-onset generalized epilepsy'. They form 16% of a series of 156 epileptic patients who were over 65 years old, and 21% of our own 100 patients.

摘要

3%的癫痫患者首次发作是在60岁之后。相较于其他年龄段,这类发作的真正性质很难确定。这个年龄段出现的大多数可逆性发作并非严重类型,晕厥更为常见。文中讨论了一些症状学方面的问题。60岁之后局灶性发作更为频繁。在一些罕见病例中(几乎全是女性),失神状态可能是首个癫痫症状。对100名年龄在60至83岁之间的患者在首次发作后进行了检查,并探讨了病因问题。讨论了以下主题:——原发性癫痫在该年龄段极为罕见的可能发病情况;——肿瘤的发生率,对于晚发性癫痫仍为孤立症状且未从专门的神经科或神经外科医院科室挑选的患者,肿瘤发生率不超过10%;——血管性癫痫的作用;在极少数情况下,但具有重大实际意义的是,癫痫可能预示着随后会发生的脑血管意外。然而,很难明确一定数量暂时无法解释的晚发性癫痫的血管起源。还考虑了其他一些病因因素:外伤史、酗酒和痴呆。作者们一致认为,在50%的病例中病因并不明显。在这组病因不明的病例中,分离出以下电临床形式似乎很有意思:——大发作癫痫,发作明显呈全身性;无特殊病理既往史;神经心理学和神经学检查正常,无智力障碍表现;脑电图通常显示轻微改变:快速节律,一些尖波;脑部扫描显示有全脑萎缩。这类患者被称为“继发性晚发性全身性癫痫”患者。在156名65岁以上的癫痫患者系列中,他们占16%,在我们自己的100名患者中占21%。

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