Lawrence W T, Talbot T L, Norton J A
Surgery. 1986 Jul;100(1):9-13.
The purpose of this study was to determine if any interval between preoperative or postoperative administration of doxorubicin hydrochloride (Adriamycin) and wounding would limit the impairment in healing induced by Adriamycin. The question was evaluated in 7 cm incisional wounds on the dorsal midline of rats. Preoperative Adriamycin was administered 42, 28, 21, 14, and 7 days before wounding, and wound breaking strengths (WBS) of the incisional wounds were measured 7, 18, and 28 days after wounding. Postoperative Adriamycin was administered 0, 7, 14, 21, and 28 days after wounding, and WBS were measured 7, 14, 28, 35, and 42 days after wounding. A similar and significant degree of impairment was induced in healing by all preoperative Adriamycin regimens evaluated. Postoperative Adriamycin administered up to 21 days after wounding induced a healing deficit that manifested 1 to 2 weeks after Adriamycin administration. Adriamycin administered 28 days after surgery induced no demonstrable impairment in WBS. In addition, Adriamycin never decreased the WBS of a wound after a certain degree of strength had been obtained. These results lead us to warn against the use of preoperative Adriamycin and support the use of postoperative Adriamycin administered 28 days after a surgical procedure.
本研究的目的是确定术前或术后给予盐酸多柔比星（阿霉素）与创伤之间的任何间隔时间是否会限制阿霉素诱导的愈合损伤。该问题在大鼠背部中线的7厘米切口伤口上进行了评估。术前阿霉素在创伤前42、28、21、14和7天给药，在创伤后7、18和28天测量切口伤口的抗张强度（WBS）。术后阿霉素在创伤后0、7、14、21和28天给药，在创伤后7、14、28、35和42天测量WBS。所有评估的术前阿霉素方案在愈合过程中均诱导了相似且显著程度的损伤。创伤后21天内给予的术后阿霉素诱导了愈合缺陷，该缺陷在阿霉素给药后1至2周出现。术后28天给予阿霉素未导致WBS出现明显损伤。此外，在获得一定程度的强度后，阿霉素从未降低伤口的WBS。这些结果使我们警告不要使用术前阿霉素，并支持在手术28天后使用术后阿霉素。
