Lawrence W T, Norton J A, Harvey A K, Gorschboth C M, Talbot T L, Grotendorst G R
J Natl Cancer Inst. 1986 Jan;76(1):119-26.
The mortality rate induced by 3 doses of iv doxorubicin was evaluated in F344 rats, and a dose of 8 mg doxorubicin/kg body weight was the maximum dose tolerated with an acceptable mortality rate. Rats treated with 8 mg doxorubicin/kg prior to or on the day of wounding demonstrated decreased wound breaking strength in incisional wounds at all intervals after wounding. Decreased amounts of collagen and DNA and less cellularity were noted in wound chambers from rats treated in the same manner. In both the incisional wound and wound chamber models, rats treated with doxorubicin 7 days after wounding showed a less dramatic healing impairment. No difference in collagen types was noted between chambers from the doxorubicin-treated and untreated rats. Doxorubicin also produced a significant reduction in platelet and white blood cell counts 1 week after it was administered. The data indicate that doxorubicin impedes healing by decreasing wound cellularity and collagen synthesis.
在F344大鼠中评估了3剂静脉注射阿霉素诱导的死亡率，阿霉素剂量为8mg/ kg体重是具有可接受死亡率的最大耐受剂量。在受伤前或受伤当天用8mg阿霉素/ kg处理的大鼠在受伤后的所有时间段，切口伤口的伤口破裂强度均降低。以相同方式处理的大鼠的伤口腔中，胶原蛋白和DNA含量减少，细胞数量也减少。在切口伤口和伤口腔模型中，受伤7天后用阿霉素处理的大鼠愈合损伤较小。阿霉素处理组和未处理组大鼠的伤口腔之间，胶原蛋白类型没有差异。阿霉素给药1周后，血小板和白细胞计数也显著降低。数据表明，阿霉素通过减少伤口细胞数量和胶原蛋白合成来阻碍愈合。
