Ingram D M
Nutr Cancer. 1981;3(2):75-80. doi: 10.1080/01635588109513705.
Trends in age-adjusted breast cancer mortality and consumption of meat, fat, sugar, cereal, and fruit and vegetables were studied for England and Wales over the 50-year period from 1928 to 1977. At the onset of World War II, there was a marked reduction in both breast cancer mortality and intake of sugar, meat and fat, and an increased consumption of cereals and vegetables. Consumption of these foodstuffs returned to pre-war levels by 1954, but breast cancer mortality did not return to pre-war levels until some 15 years later. The association between the various dietary components and subsequent breast cancer mortality was determined for various lag intervals. Significant correlations were found for cereal, fat, sugar and meat consumption, the correlation being maximal for a diet-breast cancer death lag interval of 12 years. These findings add weight to the hypothesis that breast cancer development is related to a diet rich in meat, fat and sugar, and that some protection against cancer may be afforded by a reduction in these dietary components and an increase in cereal consumption.
对1928年至1977年这50年间英格兰和威尔士年龄调整后的乳腺癌死亡率以及肉类、脂肪、糖、谷物、水果和蔬菜的消费量趋势进行了研究。第二次世界大战爆发时，乳腺癌死亡率以及糖、肉类和脂肪的摄入量均显著下降，谷物和蔬菜的消费量增加。到1954年，这些食品的消费量恢复到战前水平，但乳腺癌死亡率直到大约15年后才恢复到战前水平。针对不同的滞后间隔，确定了各种饮食成分与随后乳腺癌死亡率之间的关联。发现谷物、脂肪、糖和肉类消费之间存在显著相关性，饮食与乳腺癌死亡滞后间隔为12年时相关性最大。这些发现进一步支持了以下假设：乳腺癌的发展与富含肉类、脂肪和糖的饮食有关，减少这些饮食成分并增加谷物消费可能会提供一些抗癌保护。
