Reddy C S, Chan P K, Hayes A W
Toxicology. 1978 Nov;11(3):219-23. doi: 10.1016/s0300-483x(78)91339-2.
Teratogenicity of daily intraperitoneal (i.p.) injections of 1.5 or 2.0 mg/kg of patulin on days 6 through 17 of pregnancy and mutagenic effects of acute i.p. exposure of 3.0 mg/kg of patulin on male germ cells were evaluated. Resorption of all implanted embryos occurred at 2.0 mg/kg/day of patulin, while a significant reduction in the average body weight of 19-day-old fetuses from patulin-treated mothers, compared to control fetuses, was noticed at 1.5 mg/kg/day without any lethal effects on the implanted embryos. Patulin was embryocidal, possibly fetotoxic but was neither teratogenic nor mutagenic to mice.
评估了在妊娠第6天至第17天每天腹腔注射1.5或2.0毫克/千克棒曲霉素的致畸性，以及急性腹腔注射3.0毫克/千克棒曲霉素对雄性生殖细胞的诱变作用。当棒曲霉素剂量为2.0毫克/千克/天时，所有植入胚胎均发生吸收，而当剂量为1.5毫克/千克/天时，与对照胎儿相比，经棒曲霉素处理的母亲所生19日龄胎儿的平均体重显著降低，但对植入胚胎无任何致死作用。棒曲霉素具有胚胎毒性，可能具有胎儿毒性，但对小鼠既无致畸性也无诱变性。
