Clemow A J, Weinstein A M, Klawitter J J, Koeneman J, Anderson J
J Biomed Mater Res. 1981 Jan;15(1):73-82. doi: 10.1002/jbm.820150111.
The interfacial shear properties of bone tissue growth into porous coated Ti-6-A1-4V femoral implants have been examined as a function of the pore size of the porous surface. Three particle size range powders (297 microns, 420-500 microns, 595-707 microns) were used to fabricate cylindrical implants which were inserted into the femoral medullary canal of dogs for 6 months. Push-out tests on the removed femurs are reported and reveal: (i) that those implants residing in cortical bone exhibited significantly higher shear properties than the equivalent implants in cancellous bone and (ii) that the interfacial shear strength and stiffness decreased with increasing pore diameter within the range 175-325 microns. The extent of bone ingrowth into the surface of the implants was measured using quantitative optical microscopic techniques. This indicated that the percentage of bone which had grown into the surface was inversely proportional to the square root of the pore size and that further the shear properties of the interface were proportional to the extent of bone ingrowth.
研究了骨组织长入多孔涂层Ti-6-Al-4V股骨植入物的界面剪切特性与多孔表面孔径之间的关系。使用三种粒径范围的粉末(297微米、420 - 500微米、595 - 707微米)制作圆柱形植入物,并将其植入犬的股骨髓腔中6个月。报告了对取出的股骨进行的推出试验结果,结果显示:(i)位于皮质骨中的植入物的剪切特性显著高于松质骨中同等的植入物;(ii)在175 - 325微米范围内,界面剪切强度和刚度随孔径增大而降低。使用定量光学显微镜技术测量了骨长入植入物表面的程度。结果表明,长入表面的骨的百分比与孔径的平方根成反比,并且界面的剪切特性与骨长入的程度成正比。