Hayashi K, Inadome T, Mashima T, Sugioka Y
Department of Orthopaedic Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J Biomed Mater Res. 1993 May;27(5):557-63. doi: 10.1002/jbm.820270502.
The interface shear strength of uncoated Ti-6Al-4V, dense sintered hydroxyapatite (HA), and HA-coated Ti-6Al-4V were compared. Interface shear strength was determined using a transcortical push-out model in dogs 4 and 12 weeks after implantation. The interface shear strength of dense sintered HA and HA-coated Ti-6Al-4V was significantly higher than that of uncoated Ti-6Al-4V (P < .001). There was no significant difference between the interface shear strength of dense sintered HA and HA-coated Ti-6Al-4V. After the push-out test for HA-coated implants, the regions fractured at the bone-coating interface and at the coating-titanium interface coexisted at 4 weeks after implantation. At 12 weeks, the fracture site was, in all cases, the HA coating-titanium interface, and, in a few samples, fractures inside the coating layer also were visible.
对未涂层的Ti-6Al-4V、致密烧结羟基磷灰石（HA）以及HA涂层的Ti-6Al-4V的界面剪切强度进行了比较。在植入后4周和12周的犬类动物中，采用经皮质推出模型测定界面剪切强度。致密烧结HA和HA涂层的Ti-6Al-4V的界面剪切强度显著高于未涂层的Ti-6Al-4V（P <.001）。致密烧结HA和HA涂层的Ti-6Al-4V的界面剪切强度之间无显著差异。对HA涂层植入物进行推出试验后，植入后4周时，在骨-涂层界面和涂层-钛界面处断裂的区域并存。在12周时，所有情况下的骨折部位均为HA涂层-钛界面，并且在少数样本中，涂层内也可见骨折。
