Schulman A N, Fagen N D, Brezina M, Silver H, Nitzze A, Morton D, Gitnick G L
Gastroenterology. 1980 Feb;78(2):253-8.
The prognostic significance of the HBe-antigen (HBeAg) in the course and outcome of type B hepatitis was studied prospectively in 71 susceptible oncology patients. The patients had been exposed to tumor cell vaccines inadvertently contaminated with hepatitis B surface antigen (HBsAg)-containing plasma. Forty-five patients (63%) were infected. These 45 showed three types of acute seroresponse: HBsAg and HBeAg, 28 patients (62%); HBsAg alone, 8 patients (18%); and a primary antibody to HBsAg (anti-HBs) response, 9 patients (20%). There was no significant difference in acute course and outcome between the two HBs-antigenemic groups. All primary anti-HBs responders had asymptomatic infections. Seventeen patients receiving chemotherapy during the period of hepatitis B exposure were significantly more prone to symptomatic infection with acute HBs-antigenemia, and 2 of these patients developed chronic active hepatitis. The HBeAg is common early in acute hepatitis B among solid tumor patients and at this stage in disease has no prognostic significance independent of HBsAg.
对71名易感染的肿瘤患者进行了前瞻性研究，以探讨HBe抗原（HBeAg）在乙型肝炎病程和转归中的预后意义。这些患者因意外接触了被含乙型肝炎表面抗原（HBsAg）的血浆污染的肿瘤细胞疫苗而感染。45名患者（63%）被感染。这45名患者表现出三种急性血清反应类型：HBsAg和HBeAg阳性，28名患者（62%）；仅HBsAg阳性，8名患者（18%）；以及对HBsAg的原发性抗体（抗-HBs）反应阳性，9名患者（20%）。两个HBs抗原血症组在急性病程和转归方面无显著差异。所有原发性抗-HBs反应者均为无症状感染。在接触乙型肝炎期间接受化疗的17名患者明显更易发生伴有急性HBs抗原血症的症状性感染，其中2名患者发展为慢性活动性肝炎。HBeAg在实体瘤患者的急性乙型肝炎早期很常见，在此疾病阶段，它不具有独立于HBsAg的预后意义。
