Chipps B E, Sobotka A K, Sanders J P, Teets K C, Norman P S, Lichtenstein L M
J Allergy Clin Immunol. 1980 Jan;65(1):61-4. doi: 10.1016/0091-6749(80)90178-5.
A questionnaire survey of board-certified allergists revealed that conflicting ideas exist as to the effect that drugs such as theophylline and beta 2 agonists have an immediate skin tests. Approximately half of the respondents felt these drugs would obscure a skin response; the remainder would not withdraw the drugs prior to testing. As a result of this difference in opinion, we studied the effects of these drugs on skin tests in seven subjects taking terbutaline (5 mg three times daily) and 13 subjects taking theophylline (3 to 5 mg/kg every 6 hr). Neither an acute loading dose nor chronic administration of either drug singly produced significant changes in wheal size in response to histamine, ragweed, or grass allergens. We conclude that theophylline and terbutaline administered singly at these doses have no effect on immediate skin tests.
一项针对获得委员会认证的过敏症专科医生的问卷调查显示，对于诸如茶碱和β2激动剂等药物对即刻皮肤试验的影响，存在相互矛盾的观点。大约一半的受访者认为这些药物会掩盖皮肤反应；其余的人则不会在测试前停用这些药物。由于这种意见分歧，我们研究了这些药物对7名服用特布他林（每日3次，每次5毫克）的受试者和13名服用茶碱（每6小时3至5毫克/千克）的受试者的皮肤试验的影响。单独给予这两种药物中的任何一种，无论是急性负荷剂量还是慢性给药，对组胺、豚草或草类过敏原引起的风团大小均未产生显著变化。我们得出结论，以这些剂量单独给予茶碱和特布他林对即刻皮肤试验没有影响。
