多里多辛：一种从裸鳃亚目动物高贵异鳃海蛞蝓中提取的新型降压N-甲基嘌呤核糖苷。
Doridosine: a new hypotensive N-methylpurine riboside from the nudibranch Anisodoris nobilis.
作者信息
Fuhrman F A, Fuhrman G J, Kim Y H, Pavelka L A, Mosher H S
出版信息
Science. 1980 Jan 11;207(4427):193-5. doi: 10.1126/science.7350655.
PMID:7350655
Abstract
A new N-methylpurine riboside (doridosine), probably N1-Methylisoguanosine, was isolated from the digestive glands of a nudibranch. Doridosine produces prolonged hypotension and bradycardia in anesthetized rats, decreases the rate and the amplitude of contraction of guinea pig atria in vitro, and causes the heart rate in anesthetized mice to be reduced by 50 percent for many hours after which the animals recover completely.
摘要
从一种裸鳃亚目动物的消化腺中分离出一种新的 N-甲基嘌呤核糖苷（多里多辛），可能是 N1-甲基异鸟苷。多里多辛在麻醉大鼠中可导致长时间的低血压和心动过缓，在体外可降低豚鼠心房的收缩速率和幅度，并且使麻醉小鼠的心率在数小时内降低 50%，之后动物可完全恢复。
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