Huang Ri-Ming, Chen Yin-Ning, Zeng Ziyu, Gao Cheng-Hai, Su Xiangdong, Peng Yan
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China.
College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China.
Mar Drugs. 2014 Dec 2;12(12):5817-38. doi: 10.3390/md12125817.
Nucleosides are glycosylamines that structurally form part of nucleotide molecules, the building block of DNA and RNA. Both nucleosides and nucleotides are vital components of all living cells and involved in several key biological processes. Some of these nucleosides have been obtained from a variety of marine resources. Because of the biological importance of these compounds, this review covers 68 marine originated nucleosides and their synthetic analogs published up to June 2014. The review will focus on the structures, bioactivities, synthesis and biosynthetic processes of these compounds.
核苷是糖基胺，在结构上构成核苷酸分子的一部分，而核苷酸是DNA和RNA的组成单元。核苷和核苷酸都是所有活细胞的重要组成部分，并参与多个关键的生物过程。其中一些核苷是从多种海洋资源中获得的。由于这些化合物具有生物学重要性，本综述涵盖了截至2014年6月发表的68种海洋来源的核苷及其合成类似物。该综述将聚焦于这些化合物的结构、生物活性、合成及生物合成过程。
