Rosenberg L, Hennekens C H, Rosner B, Belanger C, Rothman K J, Speizer F E
Am J Epidemiol. 1980 Jan;111(1):59-66. doi: 10.1093/oxfordjournals.aje.a112874.
The relation of oral contraceptive (OC) use to the risk of hospitalization for myocardial infarction (MI) was evaluated among 121,964 US nurses who responded to a mail questionnaire. There were 156 women who reported having been hospitalized for MI before the menopause, and 23 (15%) were OC users at the time of the MI. Of 3120 controls matched to the cases for menopausal status at the time of the MI and for age, 304 (10%) were using OCs at the time of the MI. The apparent increase in the risk of MI for current OC users was not explained by cigarette smoking, hypertension, elevated cholesterol or other identified risk factors for MI. We estimated that OC use increased MI risk 1.8-fold overall and 2.8-fold among nonsmokers without other risk factors. The increase in risk attributable to the combined effect of current OC use, cigarette smoking and hypertension was considerably greater than what would be predicted from the sum of the separate effects of these factors.
在121964名回复邮件调查问卷的美国护士中，评估了口服避孕药（OC）的使用与因心肌梗死（MI）住院风险之间的关系。有156名女性报告在绝经前因MI住院，其中23名（15%）在发生MI时使用OC。在3120名与病例在MI发生时的绝经状态和年龄相匹配的对照中，304名（10%）在MI发生时使用OC。当前OC使用者MI风险的明显增加无法用吸烟、高血压、胆固醇升高或其他已确定的MI风险因素来解释。我们估计，总体而言，使用OC使MI风险增加1.8倍，在无其他风险因素的非吸烟者中增加2.8倍。当前OC使用、吸烟和高血压共同作用导致的风险增加远大于这些因素单独作用之和的预期值。
